Yong. Yu, et.al., Bcl11a is essential for lymphoid development and negatively regulates p53., The Journal of experimental medicine, 2012, 209

http://rdf.ncbi.nlm.nih.gov/pubmed/23230003

Yong. Yu, et.al., Bcl11a is essential for lymphoid development and negatively regulates p53., The Journal of experimental medicine, 2012, 209

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal common lymphocyte progenitor cell morphology in RBRC01190
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002235
• abnormal T cell differentiation in RBRC01190
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002225
• decreased DN2 thymocyte number in RBRC01190
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002238
• decreased hematopoietic stem cell number in RBRC01190
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002227

allele

http://purl.org/net/cito/citesAsAuthority

• Bcl11a<tm1Peli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5475335
• Bcl11a<tm2.1Peli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5475336

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased pro-B cell number_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008208I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• decreased pre-B cell number_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008209I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• increased B cell apoptosis_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008782I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• decreased hematopoietic stem cell number_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004810I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• decreased immature B cell number_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008215I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• abnormal immune system morphology_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000685I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• decreased B cell number_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005017I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• abnormal hematopoietic stem cell physiology_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010763I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• abnormal common lymphocyte progenitor cell morphology_Bcl11a<tm1Ngc>/Bcl11a<+>
  http://metadb.riken.jp/0008249I129S1SvBcl11atm1NgcBcl11aBcl11atm1NgcBcl11a
• abnormal hematopoietic stem cell physiology_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010763I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliTrp53tm1BrnTrp53tm1BrnGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26SorTrp53tm1BrnBcl11atm21PeliGtROSA26Sortm2creERT2Brn
• abnormal T cell differentiation_Bcl11a<tm1Ngc>/Bcl11a<+>
  http://metadb.riken.jp/0002145I129S1SvBcl11atm1NgcBcl11aBcl11atm1NgcBcl11a
• decreased hematopoietic stem cell number_Bcl11a<tm1Ngc>/Bcl11a<+>
  http://metadb.riken.jp/0004810I129S1SvBcl11atm1NgcBcl11aBcl11atm1NgcBcl11a
• abnormal T cell differentiation_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002145I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• decreased DN2 thymocyte number_Bcl11a<tm1Ngc>/Bcl11a<+>
  http://metadb.riken.jp/0010132I129S1SvBcl11atm1NgcBcl11aBcl11atm1NgcBcl11a
• decreased hematopoietic stem cell number_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Trp53<tm1Brn>/Trp53<tm1Brn>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004810I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliTrp53tm1BrnTrp53tm1BrnGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26SorTrp53tm1BrnBcl11atm21PeliGtROSA26Sortm2creERT2Brn
• abnormal common lymphocyte progenitor cell morphology_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008249I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor
• decreased DN2 thymocyte number_Bcl11a<tm2.1Peli>/Bcl11a<tm2.1Peli>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010132I129P2OlaHsd129S1SvBcl11atm21PeliBcl11atm21PeliGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnBcl11atm21PeliGtROSA26Sor