Guo. Fu, et.al., Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling., Nature immunology, 2009, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/19597499

Guo. Fu, et.al., Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling., Nature immunology, 2009, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD46209
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD46209
• CD31570
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD31570

allele

http://purl.org/net/cito/citesAsAuthority

• Themis<tm1Gasc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4353091

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal positive T cell selection_Tg(TcraTcrb)1100Mjb/?,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0004919I129S6SvEvTacC57BL6TgTcraTcrb1100MjbThemistm1GascThemistm1GascThemistm1GascTgTcraTcrb1100Mjb
• decreased thymocyte number_Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0000715B6129SThemistm1GascThemistm1GascThemistm1GascThemistm1Gasc
• abnormal thymus medulla morphology_Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0002375B6129SThemistm1GascThemistm1GascThemistm1GascThemistm1Gasc
• increased double-positive T cell number_Tg(TcraTcrb)1100Mjb/?,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0005091I129S6SvEvTacC57BL6TgTcraTcrb1100MjbThemistm1GascThemistm1GascThemistm1GascTgTcraTcrb1100Mjb
• abnormal positive T cell selection_Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0004919I129S6SvEvTacC57BL6DBA2TgTcraHYTcrbHY71VboThemistm1GascThemistm1GascThemistm1GascTgTcraHYTcrbHY71Vbo
• abnormal positive T cell selection_Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0004919B6129SThemistm1GascThemistm1GascThemistm1GascThemistm1Gasc
• abnormal regulatory T cell morphology_Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0004941B6129SThemistm1GascThemistm1GascThemistm1GascThemistm1Gasc
• decreased CD4-positive, alpha beta T cell number_Tg(TcrAND)53Hed/?,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0008075I129S6SvEvTacC57BL6SJLTgTcrAND53HedThemistm1GascThemistm1GascThemistm1GascTgTcrAND53Hed
• abnormal negative T cell selection_Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0004918I129S6SvEvTacC57BL6DBA2TgTcraHYTcrbHY71VboThemistm1GascThemistm1GascThemistm1GascTgTcraHYTcrbHY71Vbo
• decreased CD8-positive, alpha-beta T cell number_Tg(TcrAND)53Hed/?,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0008079I129S6SvEvTacC57BL6SJLTgTcrAND53HedThemistm1GascThemistm1GascThemistm1GascTgTcrAND53Hed
• decreased CD4-positive, alpha beta T cell number_Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0008075B6129SThemistm1GascThemistm1GascThemistm1GascThemistm1Gasc
• increased double-positive T cell number_Tg(TcrAND)53Hed/?,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0005091I129S6SvEvTacC57BL6SJLTgTcrAND53HedThemistm1GascThemistm1GascThemistm1GascTgTcrAND53Hed
• decreased CD8-positive, alpha-beta T cell number_Tg(TcraTcrb)1100Mjb/?,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0008079I129S6SvEvTacC57BL6TgTcraTcrb1100MjbThemistm1GascThemistm1GascThemistm1GascTgTcraTcrb1100Mjb
• abnormal positive T cell selection_Tg(TcrAND)53Hed/?,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0004919I129S6SvEvTacC57BL6SJLTgTcrAND53HedThemistm1GascThemistm1GascThemistm1GascTgTcrAND53Hed
• abnormal memory T cell morphology_Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0010833B6129SThemistm1GascThemistm1GascThemistm1GascThemistm1Gasc
• increased double-positive T cell number_Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0005091B6129SThemistm1GascThemistm1GascThemistm1GascThemistm1Gasc
• decreased CD8-positive, alpha-beta T cell number_Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0008079B6129SThemistm1GascThemistm1GascThemistm1GascThemistm1Gasc
• abnormal negative T cell selection_H2<b>/H2<d>,Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0004918I129S6SvEvTacC57BL6C57BL10DBA2H2bH2dThemistm1GascThemistm1GascH2dThemistm1GascH2b
• decreased T cell proliferation_Themis<tm1Gasc>/Themis<tm1Gasc>
  http://metadb.riken.jp/0005095B6129SThemistm1GascThemistm1GascThemistm1GascThemistm1Gasc