Marta. Puyol, et.al., A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma., Cancer cell, 2010, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/20609353

Marta. Puyol, et.al., A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma., Cancer cell, 2010, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD14056
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD14056
• CD02750
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02750
• CD02643
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02643

allele

http://purl.org/net/cito/citesAsAuthority

• Kras<tm2Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4844115

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased cell proliferation_Cdk4<tm2.1Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0000352I129S1Sv129X1SvJCdk4tm21BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdKrastm1BbdPolr2atm1creERT2BbdKrastm2Bbd
• increased lung non-small cell carcinoma incidence_Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0008716I129S1Sv129X1SvJKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrastm1BbdKras
• decreased tumor incidence_Cdk2<tm2Sgo>/Cdk2<tm2Sgo>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002052I129S1Sv129X1SvJCdk2tm2SgoCdk2tm2SgoKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrastm2BbdKrastm1BbdPolr2atm1creERT2BbdCdk2tm2Sgo
• increased lung non-small cell carcinoma incidence_Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0008716I129S1Sv129X1SvJKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrastm2BbdPolr2atm1creERT2BbdKrastm1Bbd
• decreased tumor incidence_Cdk4<tm2.2Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002052I129S1Sv129X1SvJCdk4tm22BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdPolr2atm1creERT2BbdKrastm1BbdKrastm2BbdCdk4tm22Bbd
• decreased tumor growth/size_Cdk4<tm2.1Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0003447I129S1Sv129X1SvJCdk4tm21BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdKrastm1BbdPolr2atm1creERT2BbdKrastm2Bbd
• premature death_Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrastm2BbdPolr2atm1creERT2BbdKrastm1Bbd
• premature death_Cdk2<tm1Sgo>/Cdk2<tm1Sgo>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJCdk2tm1SgoCdk2tm1SgoKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrasPolr2atm1creERT2BbdKrastm1BbdCdk2tm1Sgo
• early cellular replicative senescence_Cdk4<tm2.1Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0008008I129S1Sv129X1SvJCdk4tm21BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdKrastm1BbdPolr2atm1creERT2BbdKrastm2Bbd
• decreased tumor incidence_Cdk2<tm1Sgo>/Cdk2<tm1Sgo>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002052I129S1Sv129X1SvJCdk2tm1SgoCdk2tm1SgoKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrasPolr2atm1creERT2BbdKrastm1BbdCdk2tm1Sgo
• increased cell proliferation_Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0000351I129S1Sv129X1SvJKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrastm2BbdPolr2atm1creERT2BbdKrastm1Bbd
• increased adenoma incidence_Cdk6<tm1Bbd>/Cdk6<tm1Bbd>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0010383I129S1Sv129X1SvJCdk6tm1BbdCdk6tm1BbdKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk6tm1BbdKrasPolr2atm1creERT2BbdKrastm1Bbd
• increased adenocarcinoma incidence_Cdk4<tm2.1Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0009308I129S1Sv129X1SvJCdk4tm21BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdKrastm1BbdPolr2atm1creERT2BbdKrastm2Bbd
• premature death_Cdk2<tm2Sgo>/Cdk2<tm2Sgo>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJCdk2tm2SgoCdk2tm2SgoKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrastm2BbdKrastm1BbdPolr2atm1creERT2BbdCdk2tm2Sgo
• premature death_Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrastm1BbdKras
• early cellular replicative senescence_Cdk4<tm2.2Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0008008I129S1Sv129X1SvJCdk4tm22BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdPolr2atm1creERT2BbdKrastm1BbdKrastm2BbdCdk4tm22Bbd
• premature death_Cdk6<tm1Bbd>/Cdk6<tm1Bbd>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJCdk6tm1BbdCdk6tm1BbdKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk6tm1BbdKrasPolr2atm1creERT2BbdKrastm1Bbd
• increased lung non-small cell carcinoma incidence_Cdk6<tm1Bbd>/Cdk6<tm1Bbd>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0008716I129S1Sv129X1SvJCdk6tm1BbdCdk6tm1BbdKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk6tm1BbdKrasPolr2atm1creERT2BbdKrastm1Bbd
• increased tumor incidence_Cdk4<tm2.2Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002020I129S1Sv129X1SvJCdk4tm22BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdPolr2atm1creERT2BbdKrastm1BbdKrastm2BbdCdk4tm22Bbd
• decreased cell proliferation_Cdk4<tm2.2Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0000352I129S1Sv129X1SvJCdk4tm22BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdPolr2atm1creERT2BbdKrastm1BbdKrastm2BbdCdk4tm22Bbd
• increased lung tumor incidence_Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0008014I129S1Sv129X1SvJKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrastm2BbdPolr2atm1creERT2BbdKrastm1Bbd
• increased adenoma incidence_Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0010383I129S1Sv129X1SvJKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrastm1BbdKras
• decreased tumor growth/size_Cdk4<tm2.2Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0003447I129S1Sv129X1SvJCdk4tm22BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdPolr2atm1creERT2BbdKrastm1BbdKrastm2BbdCdk4tm22Bbd
• decreased tumor incidence_Cdk4<tm2.2Bbd>/Cdk4<tm2.2Bbd>,Kras<tm1Bbd>/Kras<tm1Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/0002052I129S1Sv129X1SvJCdk4tm22BbdCdk4tm22BbdKrastm1BbdKrastm1BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm22BbdKrastm1BbdPolr2atm1creERT2Bbd