Denghong. Zhang, et.al., MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice., The Journal of clinical investigation, 2010, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/20644257

Denghong. Zhang, et.al., MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice., The Journal of clinical investigation, 2010, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD09401
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD09401

allele

http://purl.org/net/cito/citesAsAuthority

• Mtor<tm1.1Gcon>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5707218

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• abnormal mitochondrial physiology_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>,Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0006036I129SvC57BL6FVBNEif4ebp1tm1NsoEif4ebp1tm1NsoMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0A1cfTgMyh6creEsr11JmkMtortm11GconEif4ebp1tm1Nso
• abnormal myocardial fiber morphology_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0000278I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• cardiac interstitial fibrosis_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>,Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0005608I129SvC57BL6FVBNEif4ebp1tm1NsoEif4ebp1tm1NsoMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0A1cfTgMyh6creEsr11JmkMtortm11GconEif4ebp1tm1Nso
• enlarged heart atrium_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0008725I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• abnormal autophagy_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>,Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0008260I129SvC57BL6FVBNEif4ebp1tm1NsoEif4ebp1tm1NsoMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0A1cfTgMyh6creEsr11JmkMtortm11GconEif4ebp1tm1Nso
• cardiac interstitial fibrosis_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0005608I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• small myocardial fiber_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0004565I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• increased heart ventricle size_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0008772I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• decreased cardiomyocyte apoptosis_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>,Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0003223I129SvC57BL6FVBNEif4ebp1tm1NsoEif4ebp1tm1NsoMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0A1cfTgMyh6creEsr11JmkMtortm11GconEif4ebp1tm1Nso
• decreased ventricle muscle contractility_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0005598I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• increased cardiac muscle contractility_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>
  http://metadb.riken.jp/0005599I129SvC57BL6Eif4ebp1tm1NsoEif4ebp1tm1NsoEif4ebp1tm1Nso
• decreased cardiac muscle contractility_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0005140I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• abnormal sarcomere morphology_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0004090I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• ascites_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0005324I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• abnormal translation_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0013272I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• abnormal myocardial fiber physiology_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>
  http://metadb.riken.jp/0004215I129SvC57BL6Eif4ebp1tm1NsoEif4ebp1tm1NsoEif4ebp1tm1Nso
• pleural effusion_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0010334I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• dilated cardiomyopathy_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0002795I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• enlarged heart_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0000274I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• abnormal autophagy_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0008260I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• abnormal mitochondrial physiology_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0006036I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• congestive heart failure_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0006138I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• increased cardiomyocyte apoptosis_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0003222I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• abnormal myocardial fiber physiology_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0004215I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• thin interventricular septum_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0010725I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• increased response of heart to induced stress_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0004485I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• premature death_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>,Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0002083I129SvC57BL6FVBNEif4ebp1tm1NsoEif4ebp1tm1NsoMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0A1cfTgMyh6creEsr11JmkMtortm11GconEif4ebp1tm1Nso
• dilated mitochondria_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0011632I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk
• thin ventricular wall_Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0
  http://metadb.riken.jp/0000280I129S1Sv129X1SvJC57BL6FVBNMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0Mtortm11GconA1cfTgMyh6creEsr11Jmk