Takatoshi. Tsuchihashi, et.al., Hand2 function in second heart field progenitors is essential for cardiogenesis., Developmental biology, 2011, 351

http://rdf.ncbi.nlm.nih.gov/pubmed/21185281

Takatoshi. Tsuchihashi, et.al., Hand2 function in second heart field progenitors is essential for cardiogenesis., Developmental biology, 2011, 351

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD19318
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD19318
• CD40836
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40836

allele

http://purl.org/net/cito/citesAsAuthority

• Hand2<tm2.1Dsr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4940061

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased heart right ventricle size_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0003649I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgNkx25cre9Eno0TgNkx25cre9EnoHand2tm1DsrHand2tm21Dsr
• lethality throughout fetal growth and development, complete penetrance_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Tbx1-cre)#Dsr/0
  http://metadb.riken.jp/0011099I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgTbx1creDsr0Hand2tm21DsrTgTbx1creDsrHand2tm1Dsr
• decreased heart right ventricle size_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Tg(Tbx1-cre)#Dsr/0
  http://metadb.riken.jp/0003649I129129S4SvJaeSor129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrGtROSA26Sortm1SorGtROSA26SorTgTbx1creDsr0TgTbx1creDsrGtROSA26SorHand2tm21DsrHand2tm1DsrGtROSA26Sortm1Sor
• thin myocardium_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Mef2c-cre)#Blk/0
  http://metadb.riken.jp/0002652I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgMef2ccreBlk0Hand2tm21DsrHand2tm1DsrTgMef2ccreBlk
• abnormal tricuspid valve morphology_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Mef2c-cre)#Blk/0
  http://metadb.riken.jp/0002624I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgMef2ccreBlk0Hand2tm21DsrHand2tm1DsrTgMef2ccreBlk
• no abnormal phenotype detected_Hand2<tm2.1Dsr>/Hand2<tm2.1Dsr>
  http://metadb.riken.jp/0002169I129C57BL6Hand2tm21DsrHand2tm21DsrHand2tm21Dsr
• abnormal cardiac outflow tract development_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Isl1<tm1(cre)Tmj>/Isl1<+>
  http://metadb.riken.jp/0006126I129129S7SvEvBrd129X1SvJC57BL6Hand2tm1DsrHand2tm21DsrIsl1tm1creTmjIsl1Hand2tm21DsrIsl1Isl1tm1creTmjHand2tm1Dsr
• heart right ventricle hypoplasia_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Isl1<tm1(cre)Tmj>/Isl1<+>
  http://metadb.riken.jp/0010422I129129S7SvEvBrd129X1SvJC57BL6Hand2tm1DsrHand2tm21DsrIsl1tm1creTmjIsl1Hand2tm21DsrIsl1Isl1tm1creTmjHand2tm1Dsr
• decreased heart right ventricle size_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Tbx1-cre)#Dsr/0
  http://metadb.riken.jp/0003649I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgTbx1creDsr0Hand2tm21DsrTgTbx1creDsrHand2tm1Dsr
• increased apoptosis_Hand2<tm1Dsr>/Hand2<tm1Dsr>
  http://metadb.riken.jp/0006042I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm1DsrHand2tm1Dsr
• embryonic lethality during organogenesis, complete penetrance_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Mef2c-cre)#Blk/0
  http://metadb.riken.jp/0011098I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgMef2ccreBlk0Hand2tm21DsrHand2tm1DsrTgMef2ccreBlk
• abnormal cardiac outflow tract development_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Tg(Tbx1-cre)#Dsr/0
  http://metadb.riken.jp/0006126I129129S4SvJaeSor129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrGtROSA26Sortm1SorGtROSA26SorTgTbx1creDsr0TgTbx1creDsrGtROSA26SorHand2tm21DsrHand2tm1DsrGtROSA26Sortm1Sor
• persistent truncus arteriosis_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Mef2c-cre)#Blk/0
  http://metadb.riken.jp/0002633I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgMef2ccreBlk0Hand2tm21DsrHand2tm1DsrTgMef2ccreBlk
• ventricular septal defect_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Mef2c-cre)#Blk/0
  http://metadb.riken.jp/0010402I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgMef2ccreBlk0Hand2tm21DsrHand2tm1DsrTgMef2ccreBlk
• embryonic lethality during organogenesis, complete penetrance_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Isl1<tm1(cre)Tmj>/Isl1<+>
  http://metadb.riken.jp/0011098I129129S7SvEvBrd129X1SvJC57BL6Hand2tm1DsrHand2tm21DsrIsl1tm1creTmjIsl1Hand2tm21DsrIsl1Isl1tm1creTmjHand2tm1Dsr
• decreased heart right ventricle size_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Mef2c-cre)#Blk/0
  http://metadb.riken.jp/0003649I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgMef2ccreBlk0Hand2tm21DsrHand2tm1DsrTgMef2ccreBlk
• heart right ventricle hypoplasia_Hand2<tm1Dsr>/Hand2<tm1Dsr>
  http://metadb.riken.jp/0010422I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm1DsrHand2tm1Dsr
• embryonic lethality during organogenesis, complete penetrance_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0011098I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgNkx25cre9Eno0TgNkx25cre9EnoHand2tm1DsrHand2tm21Dsr
• heart right ventricle hypoplasia_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Mef2c-cre)#Blk/0
  http://metadb.riken.jp/0010422I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgMef2ccreBlk0Hand2tm21DsrHand2tm1DsrTgMef2ccreBlk
• increased apoptosis_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Isl1<tm1(cre)Tmj>/Isl1<+>
  http://metadb.riken.jp/0006042I129129S7SvEvBrd129X1SvJC57BL6Hand2tm1DsrHand2tm21DsrIsl1tm1creTmjIsl1Hand2tm21DsrIsl1Isl1tm1creTmjHand2tm1Dsr
• abnormal heart development_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Isl1<tm1(cre)Tmj>/Isl1<+>
  http://metadb.riken.jp/0000267I129S4SvJaeSor129S7SvEvBrd129X1SvJC57BL6Hand2tm1DsrHand2tm21DsrGtROSA26Sortm1SorGtROSA26SorIsl1tm1creTmjIsl1GtROSA26Sortm1SorHand2tm1DsrIsl1tm1creTmjIsl1GtROSA26SorHand2tm21Dsr
• abnormal cardiac outflow tract development_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Tbx1-cre)#Dsr/0
  http://metadb.riken.jp/0006126I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgTbx1creDsr0Hand2tm21DsrTgTbx1creDsrHand2tm1Dsr
• decreased heart left ventricle size_Hand2<tm1Dsr>/Hand2<tm2.1Dsr>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0010580I129129S7SvEvBrdC57BL6Hand2tm1DsrHand2tm21DsrTgNkx25cre9Eno0TgNkx25cre9EnoHand2tm1DsrHand2tm21Dsr