amyloid beta deposits_Tg(PDGFB-APPSwInd)20Lms/0

http://metadb.riken.jp/0003329IC57BL6DBA2TgPDGFBAPPSwInd20Lms0TgPDGFBAPPSwInd20Lms

amyloid beta deposits_Tg(PDGFB-APPSwInd)20Lms/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 20, Lennart Mucke
  http://metadb.riken.jp/db/mgi_rdf/MGI:3057146

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(PDGFB-APPSwInd)20Lms/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(PDGFB-APPSwInd)20Lms

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• amyloid beta deposits
  http://purl.obolibrary.org/obo/MP_0003329

文献

http://purl.org/net/cito/citesAsAuthority

• Malcolm A. Leissring, et.al., Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death., Neuron, 2003, 40
  http://rdf.ncbi.nlm.nih.gov/pubmed/14687544
• L. Mucke, et.al., High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/10818140
• Erik D. Roberson, et.al., Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model., Science (New York, N.Y.), 2007, 316
  http://rdf.ncbi.nlm.nih.gov/pubmed/17478722