decreased regulatory T cell number_Cd80<tm1Shr>/Cd80<tm1Shr>,Cd86<tm2Shr>/Cd86<tm2Shr>

http://metadb.riken.jp/0004974I129S4SvJaeCd80tm1ShrCd80tm1ShrCd86tm2ShrCd86tm2ShrCd80tm1ShrCd86tm2Shr

decreased regulatory T cell number_Cd80<tm1Shr>/Cd80<tm1Shr>,Cd86<tm2Shr>/Cd86<tm2Shr>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• CD80 antigen
  http://metadb.riken.jp/db/mgi_rdf/MGI:101775
• CD86 antigen
  http://metadb.riken.jp/db/mgi_rdf/MGI:101773

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cd80<tm1Shr>/Cd80<tm1Shr>,Cd86<tm2Shr>/Cd86<tm2Shr>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cd80<tm1Shr>|Cd86<tm2Shr>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased regulatory T cell number
  http://purl.obolibrary.org/obo/MP_0004974

文献

http://purl.org/net/cito/citesAsAuthority

• Brian T. Fife, et.al., Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist., The Journal of clinical investigation, 2006, 116
  http://rdf.ncbi.nlm.nih.gov/pubmed/16886063
• Yinming. Liang, et.al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells., Nature immunology, 2013, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/23793062