increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>

http://metadb.riken.jp/0008014I129S4SvJaeKrastm4TyjKrasKrasKrastm4Tyj

increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<+>|Kras<tm4Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lung tumor incidence
  http://purl.obolibrary.org/obo/MP_0008014

文献

http://purl.org/net/cito/citesAsAuthority

• Alice T. Shaw, et.al., Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis., Genes & development, 2007, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/17369402
• Meng. Liu, et.al., Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20308544
• V M. Ho, et.al., The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras., Oncogene, 2009, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/19151761
• I A. Elsum, et.al., Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo., Oncogene, 2014, 33
  http://rdf.ncbi.nlm.nih.gov/pubmed/24276238