Alice T. Shaw, et.al., Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis., Genes & development, 2007, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/17369402

Alice T. Shaw, et.al., Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis., Genes & development, 2007, 21

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal bronchus morphology_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0002264I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• embryonic lethality during organogenesis, complete penetrance_Kras<tm4Tyj>/Kras<+>,Tg(Prm-cre)58Og/0
  http://metadb.riken.jp/0011098I129S4SvJaeKrastm4TyjKrasTgPrmcre58Og0KrasKrastm4TyjTgPrmcre58Og
• abnormal placenta labyrinth morphology_Kras<tm4Tyj>/Kras<+>,Tg(Prm-cre)58Og/0
  http://metadb.riken.jp/0001716I129S4SvJaeKrastm4TyjKrasTgPrmcre58Og0KrasKrastm4TyjTgPrmcre58Og
• conotruncal ridge hyperplasia_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0010588I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• increased embryonic tissue cell apoptosis_Kras<tm4Tyj>/Kras<+>,Tg(Prm-cre)58Og/0
  http://metadb.riken.jp/0013504I129S4SvJaeKrastm4TyjKrasTgPrmcre58Og0KrasKrastm4TyjTgPrmcre58Og
• increased lung tumor incidence_Kras<tm4.1Tyj>/Kras<+>,Spry2<tm1Mrt>/Spry2<tm1Mrt>
  http://metadb.riken.jp/0008014I129P2OlaHsdKrastm41TyjKrasSpry2tm1MrtSpry2tm1MrtSpry2tm1MrtKrastm41TyjKras
• increased lung tumor incidence_Kras<tm3Tyj>/Kras<+>
  http://metadb.riken.jp/0008014I129S4SvJaeKrastm3TyjKrasKrastm3TyjKras
• abnormal embryonic erythropoiesis_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0004229I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• abnormal embryonic erythrocyte morphology_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0004230I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• pale yolk sac_Kras<tm4Tyj>/Kras<+>,Tg(Prm-cre)58Og/0
  http://metadb.riken.jp/0001722I129S4SvJaeKrastm4TyjKrasTgPrmcre58Og0KrasKrastm4TyjTgPrmcre58Og
• increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>
  http://metadb.riken.jp/0008014I129S4SvJaeKrastm4TyjKrasKrasKrastm4Tyj
• pallor_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0003717I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• abnormal placental labyrinth vasculature morphology_Kras<tm4Tyj>/Kras<+>,Tg(Prm-cre)58Og/0
  http://metadb.riken.jp/0008803I129S4SvJaeKrastm4TyjKrasTgPrmcre58Og0KrasKrastm4TyjTgPrmcre58Og
• increased lung tumor incidence_Spry2<tm1Mrt>/Spry2<tm1Mrt>
  http://metadb.riken.jp/0008014I129P2OlaHsdSpry2tm1MrtSpry2tm1MrtSpry2tm1Mrt
• abnormal cardiovascular system physiology_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0001544I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• edema_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0001785I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• ventricular septal defect_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0010402I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• embryonic growth arrest_Kras<tm4Tyj>/Kras<+>,Tg(Prm-cre)58Og/0
  http://metadb.riken.jp/0001730I129S4SvJaeKrastm4TyjKrasTgPrmcre58Og0KrasKrastm4TyjTgPrmcre58Og
• dilated respiratory conducting tubes_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0010856I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• double outlet right ventricle_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0000284I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• hemorrhage_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0001914I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• abnormal bronchus epithelium morphology_Kras<tm4Tyj>/Kras<+>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0010943I129SvC57BL6Krastm4TyjKrasTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0Krastm4TyjKrasTgSFTPCrtTA5JawTgtetOcre1Jaw
• abnormal atrioventricular valve morphology_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0002745I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• postnatal lethality, complete penetrance_Kras<tm4Tyj>/Kras<+>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0011085I129SvC57BL6Krastm4TyjKrasTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0Krastm4TyjKrasTgSFTPCrtTA5JawTgtetOcre1Jaw
• abnormal branching involved in lung morphogenesis_Kras<tm4Tyj>/Kras<+>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0011024I129SvC57BL6Krastm4TyjKrasTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0Krastm4TyjKrasTgSFTPCrtTA5JawTgtetOcre1Jaw
• lethality throughout fetal growth and development, complete penetrance_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0011099I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• abnormal lung epithelium morphology_Kras<tm4Tyj>/Kras<+>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0006382I129SvC57BL6Krastm4TyjKrasTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0Krastm4TyjKrasTgSFTPCrtTA5JawTgtetOcre1Jaw
• impaired branching involved in bronchus morphogenesis_Kras<tm4Tyj>/Kras<+>,Spry2<tm1.1Mrt>/Spry2<tm1.1Mrt>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0011028I129P2OlaHsd129S4SvJaeSorFVBNKrastm4TyjKrasSpry2tm11MrtSpry2tm11MrtMeox2tm1creSorMeox2Meox2Spry2tm11MrtMeox2tm1creSorKrastm4TyjKras
• increased hepatocyte apoptosis_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0003887I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• liver hypoplasia_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0000600I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• embryonic lethality during organogenesis, incomplete penetrance_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0011108I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• impaired branching involved in bronchus morphogenesis_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0011028I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• absent vitelline blood vessels_Kras<tm4Tyj>/Kras<+>,Tg(Prm-cre)58Og/0
  http://metadb.riken.jp/0001719I129S4SvJaeKrastm4TyjKrasTgPrmcre58Og0KrasKrastm4TyjTgPrmcre58Og
• impaired branching involved in terminal bronchiole morphogenesis_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0011032I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2
• abnormal branching involved in lung morphogenesis_Kras<tm4Tyj>/Kras<+>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0011024I129S4SvJae129S4SvJaeSorKrastm4TyjKrasMeox2tm1creSorMeox2Meox2tm1creSorKrastm4TyjKrasMeox2