increased pancreatic intraepithelial neoplasia incidence_Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0

http://metadb.riken.jp/0009152I129S4SvJaeC57BL6FVBNKrastm4TyjKrasTgPdx1cre6Tuv0TgPdx1cre6TuvKrastm4TyjKras

increased pancreatic intraepithelial neoplasia incidence_Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 6, David A Tuveson
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437123
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Pdx1-cre)6Tuv|Kras<tm4Tyj>|Kras<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic intraepithelial neoplasia incidence
  http://purl.obolibrary.org/obo/MP_0009152

文献

http://purl.org/net/cito/citesAsAuthority

• Sunil R. Hingorani, et.al., Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice., Cancer cell, 2005, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/15894267
• Takashi. Yamaguchi, et.al., A genetically engineered mouse model developing rapid progressive pancreatic ductal adenocarcinoma., The Journal of pathology, 2014, 234
  http://rdf.ncbi.nlm.nih.gov/pubmed/25042889