J. Lawler, et.al., Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice., The American journal of pathology, 2001, 159

http://rdf.ncbi.nlm.nih.gov/pubmed/11696456

J. Lawler, et.al., Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice., The American journal of pathology, 2001, 159

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased adenoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0010383I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• abnormal tumor morphology_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0003448I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased hemangiosarcoma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0003667I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased carcinoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002038I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased osteosarcoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0003789I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased osteosarcoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0003789I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased sarcoma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002032I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased pancreas tumor incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0009153I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj
• increased histiocytic sarcoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009321I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased squamous cell carcinoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0004207I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased pancreas tumor incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009153I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• premature death_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002083I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj
• increased hemangiosarcoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0003667I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased carcinoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002038I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj
• increased mammary adenocarcinoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0001883I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased adenocarcinoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0009308I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj
• increased tumor incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002020I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased adenocarcinoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009308I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased carcinoma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002038I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased lymphoma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0012431I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased lung adenocarcinoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002027I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• colon polyps_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0003269I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased liver adenocarcinoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009591I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased small intestine adenocarcinoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0009309I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj
• increased fibrosarcoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0010363I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased histiocytic sarcoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009321I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased adenoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0010383I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased squamous cell carcinoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0004207I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased sarcoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002032I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• premature death_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002083I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased lymphoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0012431I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased osteosarcoma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0003789I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased sarcoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002032I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj
• increased carcinoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002038I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• gastric polyps_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0003299I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased squamous cell carcinoma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0004207I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased pancreas tumor incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009153I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• gastric polyps_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0003299I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased lung adenocarcinoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002027I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased lymphoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0012431I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased papilloma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002014I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• gastric polyps_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0003299I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased mammary adenocarcinoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0001883I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased histiocytic sarcoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0009321I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj
• increased fibrosarcoma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0010363I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• premature death_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002083I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased hemangioma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002947I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased hemangiosarcoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0003667I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj
• increased sarcoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002032I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased adenocarcinoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009308I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53Trp53tm1TyjThbs1tm1HynTrp53
• increased lymphoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0012431I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj
• intestine polyps_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0008011I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased fibrosarcoma incidence_Thbs1<tm1Hyn>/Thbs1<tm1Hyn>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0010363I129S2SvPasC57BL6Thbs1tm1HynThbs1tm1HynTrp53tm1TyjTrp53tm1TyjThbs1tm1HynTrp53tm1Tyj