David G. McFadden, et.al., The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner., Development (Cambridge, England), 2005, 132

http://rdf.ncbi.nlm.nih.gov/pubmed/15576406

David G. McFadden, et.al., The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner., Development (Cambridge, England), 2005, 132

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hand1<tm2Eno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3514024
• Tg(Nkx2-5-cre)9Eno
  http://metadb.riken.jp/db/mgi_rdf/MGI:3514028

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• no abnormal phenotype detected_Hand1<tm1Eno>/Hand1<tm2Eno>
  http://metadb.riken.jp/0002169EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand1tm2EnoHand1tm1Eno
• abnormal myocardium layer morphology_Hand1<tm1Eno>/Hand1<tm2Eno>,Hand2<tm1Eno>/Hand2<tm1Eno>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0005329EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand2tm1EnoHand2tm1EnoTgNkx25cre9Eno0Hand2tm1EnoHand1tm1EnoHand1tm2EnoTgNkx25cre9Eno
• postnatal lethality, complete penetrance_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0011085EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgNkx25cre9Eno0Hand1tm1EnoTgNkx25cre9EnoHand1tm2Eno
• thin myocardium_Hand1<tm1Eno>/Hand1<tm2Eno>,Hand2<tm1Eno>/Hand2<+>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0002652EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand2tm1EnoHand2TgNkx25cre9Eno0Hand1tm2EnoTgNkx25cre9EnoHand2Hand1tm1EnoHand2tm1Eno
• postnatal lethality, incomplete penetrance_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011086EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgMyh6cre2182Mds0Hand1tm1EnoTgMyh6cre2182MdsHand1tm2Eno
• decreased heart left ventricle size_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0010580EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgMyh6cre2182Mds0Hand1tm1EnoTgMyh6cre2182MdsHand1tm2Eno
• embryonic lethality during organogenesis, complete penetrance_Hand1<tm1Eno>/Hand1<tm2Eno>,Hand2<tm1Eno>/Hand2<+>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0011098EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand2tm1EnoHand2TgNkx25cre9Eno0Hand1tm2EnoTgNkx25cre9EnoHand2Hand1tm1EnoHand2tm1Eno
• no abnormal phenotype detected_Hand1<tm2Eno>/Hand1<tm2Eno>
  http://metadb.riken.jp/0002169EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm2EnoHand1tm2EnoHand1tm2Eno
• embryonic lethality during organogenesis, complete penetrance_Hand1<tm1Eno>/Hand1<+>,Hand2<tm1Eno>/Hand2<tm1Eno>
  http://metadb.riken.jp/0011098NSHand1tm1EnoHand1Hand2tm1EnoHand2tm1EnoHand2tm1EnoHand1tm1EnoHand1
• trabecula carnea hypoplasia_Hand1<tm1Eno>/Hand1<tm2Eno>,Hand2<tm1Eno>/Hand2<tm1Eno>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0000295EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand2tm1EnoHand2tm1EnoTgNkx25cre9Eno0Hand2tm1EnoHand1tm1EnoHand1tm2EnoTgNkx25cre9Eno
• abnormal heart morphology_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0000266EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgNkx25cre9Eno0Hand1tm1EnoTgNkx25cre9EnoHand1tm2Eno
• abnormal myocardial trabeculae morphology_Hand1<tm1Eno>/Hand1<tm2Eno>,Hand2<tm1Eno>/Hand2<+>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0002189EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand2tm1EnoHand2TgNkx25cre9Eno0Hand1tm2EnoTgNkx25cre9EnoHand2Hand1tm1EnoHand2tm1Eno
• cyanosis_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001575EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgMyh6cre2182Mds0Hand1tm1EnoTgMyh6cre2182MdsHand1tm2Eno
• double outlet right ventricle_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000284EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgMyh6cre2182Mds0Hand1tm1EnoTgMyh6cre2182MdsHand1tm2Eno
• abnormal atrioventricular cushion morphology_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000297EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgMyh6cre2182Mds0Hand1tm1EnoTgMyh6cre2182MdsHand1tm2Eno
• perimembraneous ventricular septal defect_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0010418EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgMyh6cre2182Mds0Hand1tm1EnoTgMyh6cre2182MdsHand1tm2Eno
• abnormal heart atrium morphology_Hand1<tm1Eno>/Hand1<tm2Eno>,Hand2<tm1Eno>/Hand2<tm1Eno>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0003105EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand2tm1EnoHand2tm1EnoTgNkx25cre9Eno0Hand2tm1EnoHand1tm1EnoHand1tm2EnoTgNkx25cre9Eno
• abnormal atrioventricular valve morphology_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002745EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgMyh6cre2182Mds0Hand1tm1EnoTgMyh6cre2182MdsHand1tm2Eno
• abnormal myocardium layer morphology_Hand1<tm1Eno>/Hand1<+>,Hand2<tm1Eno>/Hand2<tm1Eno>
  http://metadb.riken.jp/0005329NSHand1tm1EnoHand1Hand2tm1EnoHand2tm1EnoHand2tm1EnoHand1tm1EnoHand1
• embryonic lethality between somite formation and embryo turning, complete penetrance_Hand1<tm1Eno>/Hand1<tm2Eno>,Hand2<tm1Eno>/Hand2<tm1Eno>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0011097EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand2tm1EnoHand2tm1EnoTgNkx25cre9Eno0Hand2tm1EnoHand1tm1EnoHand1tm2EnoTgNkx25cre9Eno
• abnormal heart ventricle morphology_Hand1<tm1Eno>/Hand1<+>,Hand2<tm1Eno>/Hand2<tm1Eno>
  http://metadb.riken.jp/0005294NSHand1tm1EnoHand1Hand2tm1EnoHand2tm1EnoHand2tm1EnoHand1tm1EnoHand1
• abnormal heart ventricle morphology_Hand1<tm1Eno>/Hand1<tm2Eno>,Hand2<tm1Eno>/Hand2<tm1Eno>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0005294EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand2tm1EnoHand2tm1EnoTgNkx25cre9Eno0Hand2tm1EnoHand1tm1EnoHand1tm2EnoTgNkx25cre9Eno
• embryonic growth retardation_Hand1<tm1Eno>/Hand1<tm2Eno>,Hand2<tm1Eno>/Hand2<+>,Tg(Nkx2-5-cre)9Eno/0
  http://metadb.riken.jp/0003984EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoHand2tm1EnoHand2TgNkx25cre9Eno0Hand1tm2EnoTgNkx25cre9EnoHand2Hand1tm1EnoHand2tm1Eno
• overriding aortic valve_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000273EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgMyh6cre2182Mds0Hand1tm1EnoTgMyh6cre2182MdsHand1tm2Eno
• abnormal interventricular septum muscular part morphology_Hand1<tm1Eno>/Hand1<tm2Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0010498EI129S6SvEvTacBlackSwissorI129S6SvEvTacC57BL6Hand1tm1EnoHand1tm2EnoTgMyh6cre2182Mds0Hand1tm1EnoTgMyh6cre2182MdsHand1tm2Eno

class

http://purl.org/net/cito/citesAsAuthority

• Hand1<tm2Eno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3514024
• Tg(Nkx2-5-cre)9Eno
  http://metadb.riken.jp/db/mgi_rdf/MGI:3514028