Sergei I. Grivennikov, et.al., Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects., Immunity, 2005, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/15664162

Sergei I. Grivennikov, et.al., Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects., Immunity, 2005, 22

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tnf<tm1.1Sned>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3527143

class

http://purl.org/net/cito/citesAsAuthority

• Tnf<tm1.1Sned>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3527143

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal spleen B cell follicle morphology_Tnf<tm1Ljo>/Tnf<tm1Ljo>
  http://metadb.riken.jp/0008470I129S1SvTnftm1LjoTnftm1LjoTnftm1Ljo
• increased susceptibility to bacterial infection_Tnf<tm1Gkl>/Tnf<tm1Gkl>
  http://metadb.riken.jp/0002412I129SSvEvTnftm1GklTnftm1GklTnftm1Gkl
• decreased susceptibility to endotoxin shock_Tnf<tm1Gkl>/Tnf<tm1Gkl>
  http://metadb.riken.jp/0008734I129SSvEvTnftm1GklTnftm1GklTnftm1Gkl
• decreased susceptibility to endotoxin shock_Tnf<tm1Ljo>/Tnf<tm1Ljo>
  http://metadb.riken.jp/0008734I129S1SvTnftm1LjoTnftm1LjoTnftm1Ljo
• abnormal chemokine secretion_Tnf<tm1Gkl>/Tnf<tm1Gkl>
  http://metadb.riken.jp/0008722I129SSvEvTnftm1GklTnftm1GklTnftm1Gkl
• decreased susceptibility to autoimmune disorder_Tnf<tm1Ljo>/Tnf<tm1Ljo>
  http://metadb.riken.jp/0005351I129S1SvTnftm1LjoTnftm1LjoTnftm1Ljo
• decreased circulating tumor necrosis factor level_Tnf<tm1Ljo>/Tnf<tm1Ljo>
  http://metadb.riken.jp/0008554I129S1SvTnftm1LjoTnftm1LjoTnftm1Ljo
• increased susceptibility to bacterial infection_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002412I129C57BL6DBA2Tnftm11SnedTnftm11SnedTgCd4cre1Cwi0TgCd4cre1CwiTnftm11Sned
• increased susceptibility to bacterial infection_Tnf<tm1Ljo>/Tnf<tm1Ljo>
  http://metadb.riken.jp/0002412I129S1SvTnftm1LjoTnftm1LjoTnftm1Ljo
• decreased susceptibility to autoimmune disorder_Tnf<tm1Gkl>/Tnf<tm1Gkl>
  http://metadb.riken.jp/0005351I129SSvEvTnftm1GklTnftm1GklTnftm1Gkl
• abnormal chemokine secretion_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008722I129129P2OlaHsdC57BL6Tnftm11SnedTnftm11SnedLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Tnftm11Sned
• decreased circulating tumor necrosis factor level_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008554I129C57BL6DBA2Tnftm11SnedTnftm11SnedTgCd4cre1Cwi0TgCd4cre1CwiTnftm11Sned
• decreased susceptibility to endotoxin shock_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008734I129C57BL6DBA2Tnftm11SnedTnftm11SnedTgCd4cre1Cwi0TgCd4cre1CwiTnftm11Sned
• increased sensitivity to induced morbidity/mortality_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0009763I129C57BL6DBA2Tnftm11SnedTnftm11SnedTgCd4cre1Cwi0TgCd4cre1CwiTnftm11Sned
• hepatic necrosis_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0001654I129129P2OlaHsdC57BL6Tnftm11SnedTnftm11SnedLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Tnftm11Sned
• decreased susceptibility to autoimmune disorder_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005351I129C57BL6DBA2Tnftm11SnedTnftm11SnedTgCd4cre1Cwi0TgCd4cre1CwiTnftm11Sned
• decreased circulating tumor necrosis factor level_Tnf<tm1Gkl>/Tnf<tm1Gkl>
  http://metadb.riken.jp/0008554I129SSvEvTnftm1GklTnftm1GklTnftm1Gkl
• decreased susceptibility to autoimmune disorder_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0005351I129129P2OlaHsdC57BL6Tnftm11SnedTnftm11SnedLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Tnftm11Sned
• increased susceptibility to bacterial infection_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002412I129129P2OlaHsdC57BL6Tnftm11SnedTnftm11SnedLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Tnftm11Sned
• decreased circulating tumor necrosis factor level_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008554I129129P2OlaHsdC57BL6Tnftm11SnedTnftm11SnedLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Tnftm11Sned
• increased sensitivity to induced morbidity/mortality_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0009763I129129P2OlaHsdC57BL6Tnftm11SnedTnftm11SnedLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Tnftm11Sned
• abnormal chemokine secretion_Tnf<tm1Ljo>/Tnf<tm1Ljo>
  http://metadb.riken.jp/0008722I129S1SvTnftm1LjoTnftm1LjoTnftm1Ljo
• decreased susceptibility to endotoxin shock_Tnf<tm1.1Sned>/Tnf<tm1.1Sned>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008734I129129P2OlaHsdC57BL6Tnftm11SnedTnftm11SnedLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Tnftm11Sned

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased susceptibility to autoimmune disorder in RBRC00306
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1000697
• decreased susceptibility to endotoxin shock in RBRC00306
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1000712
• decreased susceptibility to endotoxin shock in RBRC00305
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012945
• abnormal spleen B cell follicle morphology in RBRC00306
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1000706
• decreased circulating tumor necrosis factor level in RBRC00305
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012942
• abnormal chemokine secretion in RBRC00305
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012944
• abnormal spleen B cell follicle morphology in RBRC00305
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012938
• abnormal chemokine secretion in RBRC00306
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1000711
• decreased circulating tumor necrosis factor level in RBRC00306
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1000709
• decreased susceptibility to autoimmune disorder in RBRC00305
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012929