Sean R. Christensen, et.al., Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus., Immunity, 2006, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/16973389

Sean R. Christensen, et.al., Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus., Immunity, 2006, 25

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal CD4-positive, alpha beta T cell morphology_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0002432I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• decreased double-negative T cell number_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0005089I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• increased double-negative T cell number_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0005090MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• abnormal plasmacytoid dendritic cell physiology_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0008769MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• enlarged spleen_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0000691MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• decreased autoantibody level_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0003726I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• increased IgG3 level_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0008502MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• abnormal renal glomerulus morphology_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0005325MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• glomerulonephritis_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0002743MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• increased susceptibility to systemic lupus erythematosus_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0004801MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• abnormal B cell activation_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0008217I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• increased autoantibody level_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0003725I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• abnormal lymph node size_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0000701I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• decreased susceptibility to systemic lupus erythematosus_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0004802I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• kidney inflammation_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0001859MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• decreased autoantibody level_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0003726MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• increased autoantibody level_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0003725MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• increased IgG2a level_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0008500MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• increased CD4-positive, alpha beta T cell number_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0008074MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• decreased spleen weight_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0004953I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• decreased IgG2a level_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0008496I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• increased anti-chromatin antibody level_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0004829I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• enlarged lymph nodes_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0000702MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• decreased IgG3 level_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0008498I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• increased IgG level_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0002493MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• abnormal plasmacytoid dendritic cell physiology_Fas<lpr>/Fas<lpr>,Tlr7<tm1Flv>/Y
  http://metadb.riken.jp/0008769I129S1SvC57BL6MRLMpFaslprFaslprTlr7tm1FlvYFaslprTlr7tm1Flv
• premature death_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0002083MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• abnormal B cell activation_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0008217MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki
• increased circulating interferon-alpha level_Fas<lpr>/Fas<lpr>,Tlr9<tm1Aki>/Tlr9<tm1Aki>
  http://metadb.riken.jp/0008573MRLCgTlr9tm1AkiFaslprFaslprFaslprTlr9tm1AkiTlr9tm1AkiFaslprTlr9tm1Aki