James L. Smart, et.al., Central dysregulation of the hypothalamic-pituitary-adrenal axis in neuron-specific proopiomelanocortin-deficient mice., Endocrinology, 2007, 148

http://rdf.ncbi.nlm.nih.gov/pubmed/17095588

James L. Smart, et.al., Central dysregulation of the hypothalamic-pituitary-adrenal axis in neuron-specific proopiomelanocortin-deficient mice., Endocrinology, 2007, 148

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• perinatal lethality, incomplete penetrance_Pomc<tm1Low>/Pomc<tm1Low>
  http://metadb.riken.jp/0011090I129S2SvPas129X1SvJC57BL6DBA2Pomctm1LowPomctm1LowPomctm1Low
• abnormal adrenal gland zona fasciculata morphology_Pomc<tm1Low>/Pomc<tm1Low>
  http://metadb.riken.jp/0008294I129S2SvPas129X1SvJC57BL6DBA2Pomctm1LowPomctm1LowPomctm1Low
• increased circulating adrenocorticotropin level_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0001748I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLow0Pomctm1LowTgPomcLow
• increased pituitary adenoma incidence_Pomc<tm1Low>/Pomc<+>
  http://metadb.riken.jp/0002041I129S2SvPas129X1SvJC57BL6DBA2Pomctm1LowPomcPomcPomctm1Low
• abnormal adrenal gland zona fasciculata morphology_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0008294I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLow0Pomctm1LowTgPomcLow
• decreased circulating corticosterone level_Pomc<tm1Low>/Pomc<tm1Low>
  http://metadb.riken.jp/0002665I129S2SvPas129X1SvJC57BL6DBA2Pomctm1LowPomctm1LowPomctm1Low
• decreased circulating adrenocorticotropin level_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0002664I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLow0Pomctm1LowTgPomcLow
• enlarged adrenal glands_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0000642I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLow0Pomctm1LowTgPomcLow
• increased body weight_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/Tg(Pomc)#Low
  http://metadb.riken.jp/0001260I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLowTgPomcLowPomctm1LowTgPomcLow
• increased circulating corticosterone level_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/Tg(Pomc)#Low
  http://metadb.riken.jp/0001745I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLowTgPomcLowPomctm1LowTgPomcLow
• increased circulating corticosterone level_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0001745I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLow0Pomctm1LowTgPomcLow
• abnormal corticosterone level_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0003963I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLow0Pomctm1LowTgPomcLow
• increased pituitary adenoma incidence_Pomc<tm1Low>/Pomc<+>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0002041I129C57BL6CBADBA2SwissWebsterPomctm1LowPomcTgPomcLow0Pomctm1LowPomcTgPomcLow
• decreased adrenocorticotropin level_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0005128I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLow0Pomctm1LowTgPomcLow
• decreased adrenocorticotropin level_Pomc<tm1Low>/Pomc<tm1Low>
  http://metadb.riken.jp/0005128I129S2SvPas129X1SvJC57BL6DBA2Pomctm1LowPomctm1LowPomctm1Low
• increased body weight_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0001260I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLow0Pomctm1LowTgPomcLow
• increased pituitary adenoma incidence_Pomc<tm1Low>/Pomc<tm1Low>,Tg(Pomc)#Low/0
  http://metadb.riken.jp/0002041I129C57BL6CBADBA2SwissWebsterPomctm1LowPomctm1LowTgPomcLow0Pomctm1LowTgPomcLow
• increased pituitary adenoma incidence_Pomc<tm1Low>/Pomc<tm1Low>
  http://metadb.riken.jp/0002041I129S2SvPas129X1SvJC57BL6DBA2Pomctm1LowPomctm1LowPomctm1Low
• small adrenal glands_Pomc<tm1Low>/Pomc<tm1Low>
  http://metadb.riken.jp/0002768I129S2SvPas129X1SvJC57BL6DBA2Pomctm1LowPomctm1LowPomctm1Low
• decreased circulating adrenocorticotropin level_Pomc<tm1Low>/Pomc<tm1Low>
  http://metadb.riken.jp/0002664I129S2SvPas129X1SvJC57BL6DBA2Pomctm1LowPomctm1LowPomctm1Low