Nancy L. Cho, et.al., Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice., Cancer research, 2007, 67

http://rdf.ncbi.nlm.nih.gov/pubmed/17332369

Nancy L. Cho, et.al., Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice., Cancer research, 2007, 67

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal intestinal mucosa morphology_Apc<Min>/Apc<+>
  http://metadb.riken.jp/0000511IC57BL6JApcMinApcApcApcMin
• preweaning lethality, complete penetrance_Apc<Min>/Apc<+>,Esr1<tm1.1Mma>/Esr1<tm1.1Mma>
  http://metadb.riken.jp/0011100I129S2SvPasC57BL6JApcMinApcEsr1tm11MmaEsr1tm11MmaEsr1tm11MmaApcMinApc
• abnormal colon goblet cell morphology_Apc<Min>/Apc<+>,Esr1<tm1.1Mma>/Esr1<+>
  http://metadb.riken.jp/0013795I129S2SvPasC57BL6JApcMinApcEsr1tm11MmaEsr1ApcEsr1Esr1tm11MmaApcMin
• increased gastrointestinal tumor incidence_Apc<Min>/Apc<+>,Esr1<tm1.1Mma>/Esr1<+>
  http://metadb.riken.jp/0010279I129S2SvPasC57BL6JApcMinApcEsr1tm11MmaEsr1ApcEsr1Esr1tm11MmaApcMin
• abnormal enterocyte proliferation_Apc<Min>/Apc<+>,Esr2<tm1Mma>/Esr2<tm1Mma>
  http://metadb.riken.jp/0008883I129S2SvPasC57BL6JApcMinApcEsr2tm1MmaEsr2tm1MmaApcEsr2tm1MmaApcMin
• increased colonic adenoma incidence_Apc<Min>/Apc<+>,Esr1<tm1.1Mma>/Esr1<+>
  http://metadb.riken.jp/0002044I129S2SvPasC57BL6JApcMinApcEsr1tm11MmaEsr1ApcEsr1Esr1tm11MmaApcMin
• abnormal enterocyte proliferation_Apc<Min>/Apc<+>,Esr1<tm1.1Mma>/Esr1<+>
  http://metadb.riken.jp/0008883I129S2SvPasC57BL6JApcMinApcEsr1tm11MmaEsr1ApcEsr1Esr1tm11MmaApcMin
• abnormal large intestine crypts of Lieberkuhn morphology_Apc<Min>/Apc<+>
  http://metadb.riken.jp/0004842IC57BL6JApcMinApcApcApcMin
• increased carcinoma incidence_Apc<Min>/Apc<+>,Esr1<tm1.1Mma>/Esr1<+>
  http://metadb.riken.jp/0002038I129S2SvPasC57BL6JApcMinApcEsr1tm11MmaEsr1ApcEsr1Esr1tm11MmaApcMin
• abnormal enterocyte proliferation_Apc<Min>/Apc<+>,Esr2<tm1Mma>/Esr2<+>
  http://metadb.riken.jp/0008883I129S2SvPasC57BL6JApcMinApcEsr2tm1MmaEsr2ApcApcMinEsr2tm1MmaEsr2
• abnormal intestinal mucosa morphology_Apc<Min>/Apc<+>,Esr1<tm1.1Mma>/Esr1<+>
  http://metadb.riken.jp/0000511I129S2SvPasC57BL6JApcMinApcEsr1tm11MmaEsr1ApcEsr1Esr1tm11MmaApcMin
• increased gastrointestinal tumor incidence_Apc<Min>/Apc<+>,Esr2<tm1Mma>/Esr2<+>
  http://metadb.riken.jp/0010279I129S2SvPasC57BL6JApcMinApcEsr2tm1MmaEsr2ApcApcMinEsr2tm1MmaEsr2
• increased colonic adenoma incidence_Apc<Min>/Apc<+>,Esr2<tm1Mma>/Esr2<tm1Mma>
  http://metadb.riken.jp/0002044I129S2SvPasC57BL6JApcMinApcEsr2tm1MmaEsr2tm1MmaApcEsr2tm1MmaApcMin
• abnormal enterocyte proliferation_Apc<Min>/Apc<+>
  http://metadb.riken.jp/0008883IC57BL6JApcMinApcApcApcMin
• colitis_Apc<Min>/Apc<+>,Esr2<tm1Mma>/Esr2<tm1Mma>
  http://metadb.riken.jp/0002816I129S2SvPasC57BL6JApcMinApcEsr2tm1MmaEsr2tm1MmaApcEsr2tm1MmaApcMin
• increased gastrointestinal tumor incidence_Apc<Min>/Apc<+>,Esr2<tm1Mma>/Esr2<tm1Mma>
  http://metadb.riken.jp/0010279I129S2SvPasC57BL6JApcMinApcEsr2tm1MmaEsr2tm1MmaApcEsr2tm1MmaApcMin
• abnormal large intestine crypts of Lieberkuhn morphology_Apc<Min>/Apc<+>,Esr1<tm1.1Mma>/Esr1<+>
  http://metadb.riken.jp/0004842I129S2SvPasC57BL6JApcMinApcEsr1tm11MmaEsr1ApcEsr1Esr1tm11MmaApcMin
• abnormal colon goblet cell morphology_Apc<Min>/Apc<+>,Esr2<tm1Mma>/Esr2<tm1Mma>
  http://metadb.riken.jp/0013795I129S2SvPasC57BL6JApcMinApcEsr2tm1MmaEsr2tm1MmaApcEsr2tm1MmaApcMin
• abnormal intestinal goblet cell morphology_Apc<Min>/Apc<+>
  http://metadb.riken.jp/0003449IC57BL6JApcMinApcApcApcMin