David J. Lloyd, et.al., Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr., American journal of physiology. Endocrinology and metabolism, 2008, 294

http://rdf.ncbi.nlm.nih.gov/pubmed/18160459

David J. Lloyd, et.al., Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr., American journal of physiology. Endocrinology and metabolism, 2008, 294

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating VLDL cholesterol level_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005145I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• increased circulating insulin level_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0002079I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• obese_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001261I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• increased circulating triglyceride level_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001552I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• increased circulating LDL cholesterol level_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0000182I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• abnormal circulating cholesterol level_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0000180I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• hypertension_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0000231I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• increased circulating triglyceride level_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001552I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• decreased circulating HDL cholesterol level_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0000186I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• decreased circulating HDL cholesterol level_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0000186I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• atherosclerotic lesions_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005338I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• impaired glucose tolerance_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005293I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• atherosclerotic lesions_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005338I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• abnormal circulating cholesterol level_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0000180I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• hypertension_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0000231I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• increased circulating insulin level_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0002079I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• obese_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001261I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• increased circulating free fatty acid level_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001554I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• increased circulating cholesterol level_Apob<tm2Sgy>/Apob<tm2Sgy>,Ldlr<tm1Her>/Ldlr<tm1Her>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005178I129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyLdlrtm1HerLdlrtm1HerLepobLepobLepobApobtm2SgyLdlrtm1Her
• increased circulating cholesterol level_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005178I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• hyperglycemia_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001559I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy
• increased circulating free fatty acid level_Apob<tm2Sgy>/Apob<tm2Sgy>,Apoe<tm1Unc>/Apoe<tm1Unc>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001554I129P2OlaHsd129S7SvEvBrdC57BL6Apobtm2SgyApobtm2SgyApoetm1UncApoetm1UncLepobLepobLepobApoetm1UncApobtm2Sgy