Takeshi. Egawa, et.al., ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage., Nature immunology, 2008, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/18776905

Takeshi. Egawa, et.al., ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage., Nature immunology, 2008, 9

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Zbtb7b<tm1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3821617
• Runx3<tm1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3818488
• Zbtb7b<tm1.2Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3821621
• Zbtb7b<tm1.1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3821618

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased CD4-positive, alpha beta T cell number_Cbfb<tm1Itan>/Cbfb<tm1Itan>,Zbtb7b<tm2Litt>/Zbtb7b<tm1.2Litt>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0008075I129P2OlaHsdC57BL6Cbfbtm1ItanCbfbtm1ItanZbtb7btm2LittZbtb7btm12LittTgLckcre1Cwi0Cbfbtm1ItanTgLckcre1CwiZbtb7btm2LittZbtb7btm12Litt
• abnormal T cell differentiation_Cbfb<tm1Itan>/Cbfb<tm1Itan>,Zbtb7b<tm2Litt>/Zbtb7b<tm1.2Litt>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0002145I129P2OlaHsdC57BL6Cbfbtm1ItanCbfbtm1ItanZbtb7btm2LittZbtb7btm12LittTgLckcre1Cwi0Cbfbtm1ItanTgLckcre1CwiZbtb7btm2LittZbtb7btm12Litt
• increased CD8-positive, alpha-beta T cell number_Zbtb7b<tm1Litt>/Zbtb7b<tm1.2Litt>
  http://metadb.riken.jp/0008078IC57BL6Zbtb7btm1LittZbtb7btm12LittZbtb7btm12LittZbtb7btm1Litt
• abnormal T cell differentiation_Cbfb<tm1Itan>/Cbfb<tm1Itan>,Zbtb7b<tm2Litt>/Zbtb7b<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0002145I129P2OlaHsdC57BL6Cbfbtm1ItanCbfbtm1ItanZbtb7btm2LittZbtb7bTgLckcre1Cwi0Cbfbtm1ItanZbtb7bTgLckcre1CwiZbtb7btm2Litt
• decreased CD4-positive, alpha beta T cell number_Zbtb7b<tm2Litt>/Zbtb7b<tm1.2Litt>,Tg(Lck-cre)1Cwi/?
  http://metadb.riken.jp/0008075I129P2OlaHsdC57BL6Zbtb7btm2LittZbtb7btm12LittTgLckcre1CwiTgLckcre1CwiZbtb7btm2LittZbtb7btm12Litt
• decreased CD4-positive, alpha beta T cell number_Cbfb<tm1Itan>/Cbfb<tm1Itan>,Zbtb7b<tm2Litt>/Zbtb7b<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0008075I129P2OlaHsdC57BL6Cbfbtm1ItanCbfbtm1ItanZbtb7btm2LittZbtb7bTgLckcre1Cwi0Cbfbtm1ItanZbtb7bTgLckcre1CwiZbtb7btm2Litt
• abnormal double-positive T cell morphology_Zbtb7b<tm1Litt>/Zbtb7b<tm1.2Litt>
  http://metadb.riken.jp/0002408IC57BL6Zbtb7btm1LittZbtb7btm12LittZbtb7btm12LittZbtb7btm1Litt
• abnormal CD8-positive, alpha-beta T cell differentiation_Runx3<tm1Litt>/Runx3<tm1Litt>
  http://metadb.riken.jp/0008080I129P2OlaHsdRunx3tm1LittRunx3tm1LittRunx3tm1Litt
• abnormal T cell differentiation_Zbtb7b<tm2Litt>/Zbtb7b<tm1.2Litt>,Tg(Lck-cre)1Cwi/?
  http://metadb.riken.jp/0002145I129P2OlaHsdC57BL6Zbtb7btm2LittZbtb7btm12LittTgLckcre1CwiTgLckcre1CwiZbtb7btm2LittZbtb7btm12Litt
• increased interferon-gamma secretion_Zbtb7b<tm1Litt>/Zbtb7b<tm1.2Litt>
  http://metadb.riken.jp/0008566IC57BL6Zbtb7btm1LittZbtb7btm12LittZbtb7btm12LittZbtb7btm1Litt
• decreased CD4-positive, alpha beta T cell number_Zbtb7b<tm1Litt>/Zbtb7b<tm1.2Litt>
  http://metadb.riken.jp/0008075IC57BL6Zbtb7btm1LittZbtb7btm12LittZbtb7btm12LittZbtb7btm1Litt
• abnormal double-positive T cell morphology_Runx3<tm1Litt>/Runx3<tm1Litt>
  http://metadb.riken.jp/0002408I129P2OlaHsdRunx3tm1LittRunx3tm1LittRunx3tm1Litt
• decreased CD4-positive, alpha beta T cell number_Zbtb7b<tm2Litt>/Zbtb7b<tm1.2Litt>
  http://metadb.riken.jp/0008075I129P2OlaHsdZbtb7btm2LittZbtb7btm12LittZbtb7btm12LittZbtb7btm2Litt
• abnormal CD8-positive, alpha-beta T cell differentiation_B2m<tm1Jae>/B2m<tm1Jae>,Zbtb7b<tm1Litt>/Zbtb7b<tm1.2Litt>
  http://metadb.riken.jp/0008080I129S2SvPasC57BL6B2mtm1JaeB2mtm1JaeZbtb7btm1LittZbtb7btm12LittZbtb7btm1LittB2mtm1JaeZbtb7btm12Litt
• abnormal double-positive T cell morphology_B2m<tm1Jae>/B2m<tm1Jae>,Zbtb7b<tm1Litt>/Zbtb7b<tm1.2Litt>
  http://metadb.riken.jp/0002408I129S2SvPasC57BL6B2mtm1JaeB2mtm1JaeZbtb7btm1LittZbtb7btm12LittZbtb7btm1LittB2mtm1JaeZbtb7btm12Litt

class

http://purl.org/net/cito/citesAsAuthority

• Zbtb7b<tm1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3821617
• Runx3<tm1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3818488
• Zbtb7b<tm1.2Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3821621
• Zbtb7b<tm1.1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3821618