Samira. Alliouachene, et.al., Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation., The Journal of clinical investigation, 2008, 118

http://rdf.ncbi.nlm.nih.gov/pubmed/18846252

Samira. Alliouachene, et.al., Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation., The Journal of clinical investigation, 2008, 118

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pancreatic beta cell physiology_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>
  http://metadb.riken.jp/0003562B6129P2Rps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1Gtho
• decreased circulating insulin level_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>,Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0002727B6CgRps6kb1tm1GthoTgIns2Akt13MbbRps6kb1tm1GthoRps6kb1tm1GthoTgIns2Akt13Mbb0TgIns2Akt13MbbRps6kb1tm1Gtho
• abnormal pancreatic beta cell morphology_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0005217B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• increased insulin sensitivity_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>,Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0002891B6CgRps6kb1tm1GthoTgIns2Akt13MbbRps6kb1tm1GthoRps6kb1tm1GthoTgIns2Akt13Mbb0TgIns2Akt13MbbRps6kb1tm1Gtho
• improved glucose tolerance_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0005292B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• increased circulating insulin level_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0002079B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• decreased pancreatic beta cell mass_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>
  http://metadb.riken.jp/0009114B6129P2Rps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1Gtho
• increased pancreas tumor incidence_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0009153B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• hypoglycemia_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0000189B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• decreased circulating insulin level_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>
  http://metadb.riken.jp/0002727B6129P2Rps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1Gtho
• decreased circulating glucose level_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>,Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0005560B6CgRps6kb1tm1GthoTgIns2Akt13MbbRps6kb1tm1GthoRps6kb1tm1GthoTgIns2Akt13Mbb0TgIns2Akt13MbbRps6kb1tm1Gtho
• increased pancreatic islet cell carcinoma incidence_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0010348B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• abnormal pancreatic beta cell morphology_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>,Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0005217B6CgRps6kb1tm1GthoTgIns2Akt13MbbRps6kb1tm1GthoRps6kb1tm1GthoTgIns2Akt13Mbb0TgIns2Akt13MbbRps6kb1tm1Gtho
• abnormal pancreatic beta cell morphology_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>,Rps6kb2<tm1Gtho>/Rps6kb2<tm1Gtho>,Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0005217I129P2OlaHsdC57BL6SJLRps6kb1tm1GthoRps6kb1tm1GthoRps6kb2tm1GthoRps6kb2tm1GthoTgIns2Akt13Mbb0TgIns2Akt13MbbRps6kb1tm1GthoRps6kb2tm1Gtho
• premature death_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0002083B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• pancreas fibrosis_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0003334B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• increased pancreatic beta cell mass_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0009113B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• decreased body weight_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>
  http://metadb.riken.jp/0001262B6129P2Rps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1Gtho
• abnormal pancreatic beta cell morphology_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>
  http://metadb.riken.jp/0005217B6129P2Rps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1Gtho
• increased insulin sensitivity_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>
  http://metadb.riken.jp/0002891B6129P2Rps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1GthoRps6kb1tm1Gtho
• decreased body weight_Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>,Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0001262B6CgRps6kb1tm1GthoTgIns2Akt13MbbRps6kb1tm1GthoRps6kb1tm1GthoTgIns2Akt13Mbb0TgIns2Akt13MbbRps6kb1tm1Gtho
• increased insulinoma incidence_Rps6kb2<tm1Gtho>/Rps6kb2<tm1Gtho>,Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0003364B6CgRps6kb2tm1GthoTgIns2Akt13MbbRps6kb2tm1GthoRps6kb2tm1GthoTgIns2Akt13Mbb0Rps6kb2tm1GthoTgIns2Akt13Mbb
• enlarged pancreatic islets_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0009171B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• abnormal pancreatic islet morphology_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0005215B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb
• increased insulinoma incidence_Tg(Ins2-Akt1*)3Mbb/0
  http://metadb.riken.jp/0003364B6CgTgIns2Akt13MbbTgIns2Akt13Mbb0TgIns2Akt13Mbb