Jason. Newbern, et.al., Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

http://rdf.ncbi.nlm.nih.gov/pubmed/18952847

Jason. Newbern, et.al., Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• cleft palate_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000111I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaTgWnt1cre11Rth0Mapk1tm1GelaTgWnt1cre11Rth
• small pharyngeal arch_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0006346I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• mandible hypoplasia_Srf<tm1Rmn>/Srf<tm1Rmn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000460I129S6SvEvTacC57BL6JCBAJSrftm1RmnSrftm1RmnTgWnt1cre11Rth0TgWnt1cre11RthSrftm1Rmn
• absent mandible_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000087I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• absent tongue_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0009905I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3TgWnt1cre11Rth0Mapk1tm1GelaMapk3tm1GelaTgWnt1cre11RthMapk3
• absent tongue_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0009905I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• abnormal thyroid gland morphology_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000681I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3TgWnt1cre11Rth0Mapk1tm1GelaMapk3tm1GelaTgWnt1cre11RthMapk3
• abnormal thyroid gland morphology_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000681I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• short maxilla_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000097I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• abnormal eye distance/ position_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001299I129SvC57BL6JCBAJSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgWnt1cre11Rth0Map2k2tm1ChrnTgWnt1cre11RthMap2k1tm1Chrn
• abnormal thyroid gland morphology_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000681I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• small thyroid gland_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002951I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• ventricular septal defect_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010402I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3TgWnt1cre11Rth0Mapk1tm1GelaMapk3tm1GelaTgWnt1cre11RthMapk3
• persistent truncus arteriosis_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633I129SvC57BL6JCBAJSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgWnt1cre11Rth0Map2k2tm1ChrnTgWnt1cre11RthMap2k1tm1Chrn
• abnormal thymus morphology_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000703I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3TgWnt1cre11Rth0Mapk1tm1GelaMapk3tm1GelaTgWnt1cre11RthMapk3
• mandible hypoplasia_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000460I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3TgWnt1cre11Rth0Mapk1tm1GelaMapk3tm1GelaTgWnt1cre11RthMapk3
• mandible hypoplasia_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000460I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaTgWnt1cre11Rth0Mapk1tm1GelaTgWnt1cre11Rth
• persistent truncus arteriosis_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3TgWnt1cre11Rth0Mapk1tm1GelaMapk3tm1GelaTgWnt1cre11RthMapk3
• ventricular septal defect_Srf<tm1Rmn>/Srf<tm1Rmn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010402I129S6SvEvTacC57BL6JCBAJSrftm1RmnSrftm1RmnTgWnt1cre11Rth0TgWnt1cre11RthSrftm1Rmn
• persistent truncus arteriosis_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• cleft palate_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000111I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3TgWnt1cre11Rth0Mapk1tm1GelaMapk3tm1GelaTgWnt1cre11RthMapk3
• double outlet right ventricle_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000284I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• mandible hypoplasia_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000460I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• persistent truncus arteriosis_Srf<tm1Rmn>/Srf<tm1Rmn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633I129S6SvEvTacC57BL6JCBAJSrftm1RmnSrftm1RmnTgWnt1cre11Rth0TgWnt1cre11RthSrftm1Rmn
• abnormal eye distance/ position_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001299I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3TgWnt1cre11Rth0Mapk1tm1GelaMapk3tm1GelaTgWnt1cre11RthMapk3
• embryonic lethality, complete penetrance_Srf<tm1Rmn>/Srf<tm1Rmn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0011092I129S6SvEvTacC57BL6JCBAJSrftm1RmnSrftm1RmnTgWnt1cre11Rth0TgWnt1cre11RthSrftm1Rmn
• short maxilla_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000097I129SvC57BL6JCBAJSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgWnt1cre11Rth0Map2k2tm1ChrnTgWnt1cre11RthMap2k1tm1Chrn
• ventricular septal defect_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010402I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaTgWnt1cre11Rth0Mapk1tm1GelaTgWnt1cre11Rth
• absent tongue_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0009905I129SvC57BL6JCBAJSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgWnt1cre11Rth0Map2k2tm1ChrnTgWnt1cre11RthMap2k1tm1Chrn
• short maxilla_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000097I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• lethality throughout fetal growth and development, complete penetrance_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0011099I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• lethality throughout fetal growth and development, complete penetrance_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0011099I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaTgWnt1cre11Rth0Mapk1tm1GelaTgWnt1cre11Rth
• abnormal thyroid gland morphology_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000681I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaTgWnt1cre11Rth0Mapk1tm1GelaTgWnt1cre11Rth
• mandible hypoplasia_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000460I129SvC57BL6JCBAJSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgWnt1cre11Rth0Map2k2tm1ChrnTgWnt1cre11RthMap2k1tm1Chrn
• small thymus_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000706I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• short maxilla_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000097I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaTgWnt1cre11Rth0Mapk1tm1GelaTgWnt1cre11Rth
• decreased body length_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001258I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• athymia_Srf<tm1Rmn>/Srf<tm1Rmn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000705I129S6SvEvTacC57BL6JCBAJSrftm1RmnSrftm1RmnTgWnt1cre11Rth0TgWnt1cre11RthSrftm1Rmn
• abnormal eye distance/ position_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001299I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• absent thyroid gland_Srf<tm1Rmn>/Srf<tm1Rmn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0005314I129S6SvEvTacC57BL6JCBAJSrftm1RmnSrftm1RmnTgWnt1cre11Rth0TgWnt1cre11RthSrftm1Rmn
• persistent truncus arteriosis_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• short maxilla_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000097I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3TgWnt1cre11Rth0Mapk1tm1GelaMapk3tm1GelaTgWnt1cre11RthMapk3
• absent outer ear_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0005579I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• double outlet right ventricle_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000284I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaTgWnt1cre11Rth0Mapk1tm1GelaTgWnt1cre11Rth
• abnormal thymus morphology_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000703I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaTgWnt1cre11Rth0Mapk1tm1GelaTgWnt1cre11Rth
• ventricular septal defect_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010402I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• athymia_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000705I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• abnormal outer ear morphology_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002177I129SvC57BL6JCBAJSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgWnt1cre11Rth0Map2k2tm1ChrnTgWnt1cre11RthMap2k1tm1Chrn
• ventricular septal defect_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Mapk3<tm1Gela>/Mapk3<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010402I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaMapk3tm1GelaMapk3tm1GelaTgWnt1cre11Rth0Mapk3tm1GelaTgWnt1cre11RthMapk1tm1Gela
• abnormal conotruncus morphology_Braf<tm1Wds>/Braf<tm1Wds>,Raf1<tm2Bacc>/Raf1<tm2Bacc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010583I129P2OlaHsdC57BL6JCBAJBraftm1WdsBraftm1WdsRaf1tm2BaccRaf1tm2BaccTgWnt1cre11Rth0TgWnt1cre11RthRaf1tm2BaccBraftm1Wds
• persistent truncus arteriosis_Mapk1<tm1Gela>/Mapk1<tm1Gela>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633I129S1Sv129X1SvJC57BL6JCBAJMapk1tm1GelaMapk1tm1GelaTgWnt1cre11Rth0Mapk1tm1GelaTgWnt1cre11Rth