Susanne. Herroeder, et.al., Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility., Immunity, 2009, 30

http://rdf.ncbi.nlm.nih.gov/pubmed/19409815

Susanne. Herroeder, et.al., Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility., Immunity, 2009, 30

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Arhgef12<tm1.1Wet>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3849180

class

http://purl.org/net/cito/citesAsAuthority

• Arhgef12<tm1.1Wet>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3849180

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased susceptibility to type IV hypersensitivity reaction_Gna12<tm1Citb>/Gna12<tm1Citb>,Gna13<tm2.1Soff>/Gna13<tm2.1Soff>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0005617I129S1SvC57BL6CBAGna12tm1CitbGna12tm1CitbGna13tm21SoffGna13tm21SoffTgLckcre548Jxm0Gna12tm1CitbGna13tm21SoffTgLckcre548Jxm
• increased interleukin-2 secretion_Gna12<tm1Citb>/Gna12<tm1Citb>,Gna13<tm2.1Soff>/Gna13<tm2.1Soff>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0008687I129S1SvC57BL6CBAGna12tm1CitbGna12tm1CitbGna13tm21SoffGna13tm21SoffTgLckcre548Jxm0Gna12tm1CitbGna13tm21SoffTgLckcre548Jxm
• increased CD8-positive, alpha-beta T cell number_Gna12<tm1Citb>/Gna12<tm1Citb>,Gna13<tm2.1Soff>/Gna13<tm2.1Soff>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0008078I129S1SvC57BL6CBAGna12tm1CitbGna12tm1CitbGna13tm21SoffGna13tm21SoffTgLckcre548Jxm0Gna12tm1CitbGna13tm21SoffTgLckcre548Jxm
• abnormal T cell proliferation_Arhgef12<tm1.1Wet>/Arhgef12<tm1.1Wet>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0005094I129C57BL6CBAArhgef12tm11WetArhgef12tm11WetTgLckcre548Jxm0TgLckcre548JxmArhgef12tm11Wet
• increased CD4-positive, alpha beta T cell number_Gna12<tm1Citb>/Gna12<tm1Citb>,Gna13<tm2.1Soff>/Gna13<tm2.1Soff>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0008074I129S1SvC57BL6CBAGna12tm1CitbGna12tm1CitbGna13tm21SoffGna13tm21SoffTgLckcre548Jxm0Gna12tm1CitbGna13tm21SoffTgLckcre548Jxm
• abnormal CD4-positive, alpha-beta T cell physiology_Gna12<tm1Citb>/Gna12<tm1Citb>,Gna13<tm2.1Soff>/Gna13<tm2.1Soff>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0005463I129S1SvC57BL6CBAGna12tm1CitbGna12tm1CitbGna13tm21SoffGna13tm21SoffTgLckcre548Jxm0Gna12tm1CitbGna13tm21SoffTgLckcre548Jxm
• thymus hyperplasia_Gna12<tm1Citb>/Gna12<tm1Citb>,Gna13<tm2.1Soff>/Gna13<tm2.1Soff>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0000708I129S1SvC57BL6CBAGna12tm1CitbGna12tm1CitbGna13tm21SoffGna13tm21SoffTgLckcre548Jxm0Gna12tm1CitbGna13tm21SoffTgLckcre548Jxm
• lymph node hyperplasia_Gna12<tm1Citb>/Gna12<tm1Citb>,Gna13<tm2.1Soff>/Gna13<tm2.1Soff>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0008102I129S1SvC57BL6CBAGna12tm1CitbGna12tm1CitbGna13tm21SoffGna13tm21SoffTgLckcre548Jxm0Gna12tm1CitbGna13tm21SoffTgLckcre548Jxm
• increased T cell proliferation_Gna12<tm1Citb>/Gna12<tm1Citb>,Gna13<tm2.1Soff>/Gna13<tm2.1Soff>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0005348I129S1SvC57BL6CBAGna12tm1CitbGna12tm1CitbGna13tm21SoffGna13tm21SoffTgLckcre548Jxm0Gna12tm1CitbGna13tm21SoffTgLckcre548Jxm
• increased susceptibility to autoimmune diabetes_Gna12<tm1Citb>/Gna12<tm1Citb>,Gna13<tm2.1Soff>/Gna13<tm2.1Soff>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0004803I129S1SvC57BL6CBAGna12tm1CitbGna12tm1CitbGna13tm21SoffGna13tm21SoffTgLckcre548Jxm0Gna12tm1CitbGna13tm21SoffTgLckcre548Jxm

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD20303
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD20303