Nailing. Zhang, et.al., The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals., Developmental cell, 2010, 19

http://rdf.ncbi.nlm.nih.gov/pubmed/20643348

Nailing. Zhang, et.al., The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals., Developmental cell, 2010, 19

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Yap1<tm1.1Dupa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4819826
• Yap1<tm1.2Dupa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4819827

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased hepatocellular carcinoma incidence_Kras<tm4Tyj>/Kras<tm4Tyj>,Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003331I129P2OlaHsd129S4SvJaeC57BL6DBAKrastm4TyjKrastm4TyjYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0Yap1tm11DupaKrastm4TyjTgAlbcre21Mgn
• abnormal lens epithelium morphology_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003237I129P2OlaHsdC57BL6SJLNf2tm2GthNf2tm2GthTgNescre1Kln0Nf2tm2GthTgNescre1Kln
• liver fibrosis_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003333I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• increased hepatocyte proliferation_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003893I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• pale liver_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000603I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• abnormal bile duct development_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002929I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• increased hepatobiliary system tumor incidence_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0010297I129P2OlaHsdC57BL6DBANf2tm2GthNf2tm2GthTgAlbcre21Mgn0TgAlbcre21MgnNf2tm2Gth
• abnormal hepatocyte morphology_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000607I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• cataract_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001304I129P2OlaHsdC57BL6SJLNf2tm2GthNf2tm2GthTgNescre1Kln0Nf2tm2GthTgNescre1Kln
• increased circulating alanine transaminase level_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002941I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• enlarged liver_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000599I129P2OlaHsdC57BL6DBANf2tm2GthNf2tm2GthTgAlbcre21Mgn0TgAlbcre21MgnNf2tm2Gth
• enlarged liver_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000599I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• enlarged liver_Nf2<tm2Gth>/Nf2<tm2Gth>,Yap1<tm1.1Dupa>/Yap1<+>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000599I129P2OlaHsdC57BL6DBANf2tm2GthNf2tm2GthYap1tm11DupaYap1TgAlbcre21Mgn0TgAlbcre21MgnYap1Nf2tm2GthYap1tm11Dupa
• hepatic steatosis_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002628I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• abnormal liver morphology_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000598I129P2OlaHsdC57BL6DBANf2tm2GthNf2tm2GthTgAlbcre21Mgn0TgAlbcre21MgnNf2tm2Gth
• preweaning lethality, complete penetrance_Yap1<tm1.2Dupa>/Yap1<tm1.2Dupa>
  http://metadb.riken.jp/0011100NSYap1tm12DupaYap1tm12DupaYap1tm12Dupa
• bile duct hyperplasia_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004839I129P2OlaHsdC57BL6DBANf2tm2GthNf2tm2GthTgAlbcre21Mgn0TgAlbcre21MgnNf2tm2Gth
• increased hepatocellular carcinoma incidence_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003331I129P2OlaHsdC57BL6DBANf2tm2GthNf2tm2GthTgAlbcre21Mgn0TgAlbcre21MgnNf2tm2Gth
• increased hepatocyte apoptosis_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003887I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• bile duct proliferation_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003255I129P2OlaHsdC57BL6DBANf2tm2GthNf2tm2GthTgAlbcre21Mgn0TgAlbcre21MgnNf2tm2Gth
• increased circulating bilirubin level_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005344I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• abnormal lens morphology_Nf2<tm2Gth>/Nf2<tm2Gth>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001303I129P2OlaHsdC57BL6SJLNf2tm2GthNf2tm2GthTgNescre1Kln0Nf2tm2GthTgNescre1Kln
• abnormal bile duct morphology_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002928I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa
• liver cirrhosis_Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003046I129P2OlaHsdC57BL6DBAYap1tm11DupaYap1tm11DupaTgAlbcre21Mgn0TgAlbcre21MgnYap1tm11Dupa

class

http://purl.org/net/cito/citesAsAuthority

• Yap1<tm1.1Dupa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4819826
• Yap1<tm1.2Dupa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4819827

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD10866
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD10866
• CD11883
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD11883
• CD28789
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD28789