Kathryn C. Claiborn, et.al., Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice., The Journal of clinical investigation, 2010, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/20811152

Kathryn C. Claiborn, et.al., Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice., The Journal of clinical investigation, 2010, 120

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pancreatic beta cell physiology_Spop<Gt(BGB118)Byg>/Spop<+>
  http://metadb.riken.jp/0003562I129P2OlaHsdC57BL6SpopGtBGB118BygSpopSpopSpopGtBGB118Byg
• decreased insulin secretion_Pdx1<tm1Cvw>/Pdx1<+>
  http://metadb.riken.jp/0003059I129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1Pdx1Pdx1tm1Cvw
• small pancreatic islets_Pdx1<tm1Cvw>/Pdx1<+>
  http://metadb.riken.jp/0009172I129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1Pdx1Pdx1tm1Cvw
• improved glucose tolerance_Pdx1<tm1Cvw>/Pdx1<+>,Spop<Gt(BGB118)Byg>/Spop<+>
  http://metadb.riken.jp/0005292I129P2OlaHsd129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1SpopGtBGB118BygSpopPdx1SpopPdx1tm1CvwSpopGtBGB118Byg
• increased pancreatic beta cell apoptosis_Pdx1<tm1Cvw>/Pdx1<+>
  http://metadb.riken.jp/0014117I129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1Pdx1Pdx1tm1Cvw
• disorganized pancreatic islets_Pdx1<tm1Cvw>/Pdx1<+>
  http://metadb.riken.jp/0009254I129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1Pdx1Pdx1tm1Cvw
• increased circulating glucose level_Pdx1<tm1Cvw>/Pdx1<+>
  http://metadb.riken.jp/0005559I129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1Pdx1Pdx1tm1Cvw
• decreased insulin secretion_Pdx1<tm1Cvw>/Pdx1<+>,Spop<Gt(BGB118)Byg>/Spop<+>
  http://metadb.riken.jp/0003059I129P2OlaHsd129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1SpopGtBGB118BygSpopPdx1SpopPdx1tm1CvwSpopGtBGB118Byg
• abnormal pancreatic islet size_Pdx1<tm1Cvw>/Pdx1<+>
  http://metadb.riken.jp/0009170I129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1Pdx1Pdx1tm1Cvw
• increased pancreatic beta cell mass_Spop<Gt(BGB118)Byg>/Spop<Gt(BGB118)Byg>
  http://metadb.riken.jp/0009113I129P2OlaHsdC57BL6SpopGtBGB118BygSpopGtBGB118BygSpopGtBGB118Byg
• perinatal lethality, complete penetrance_Spop<Gt(BGB118)Byg>/Spop<Gt(BGB118)Byg>
  http://metadb.riken.jp/0011089I129P2OlaHsdC57BL6SpopGtBGB118BygSpopGtBGB118BygSpopGtBGB118Byg
• abnormal pancreatic islet cell apoptosis_Spop<Gt(BGB118)Byg>/Spop<+>
  http://metadb.riken.jp/0009488I129P2OlaHsdC57BL6SpopGtBGB118BygSpopSpopSpopGtBGB118Byg
• impaired glucose tolerance_Pdx1<tm1Cvw>/Pdx1<+>
  http://metadb.riken.jp/0005293I129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1Pdx1Pdx1tm1Cvw
• abnormal pancreatic beta cell physiology_Pdx1<tm1Cvw>/Pdx1<+>,Spop<Gt(BGB118)Byg>/Spop<+>
  http://metadb.riken.jp/0003562I129P2OlaHsd129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1SpopGtBGB118BygSpopPdx1SpopPdx1tm1CvwSpopGtBGB118Byg
• increased circulating glucose level_Pdx1<tm1Cvw>/Pdx1<+>,Spop<Gt(BGB118)Byg>/Spop<+>
  http://metadb.riken.jp/0005559I129P2OlaHsd129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1SpopGtBGB118BygSpopPdx1SpopPdx1tm1CvwSpopGtBGB118Byg
• disorganized pancreatic islets_Pdx1<tm1Cvw>/Pdx1<+>,Spop<Gt(BGB118)Byg>/Spop<+>
  http://metadb.riken.jp/0009254I129P2OlaHsd129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1SpopGtBGB118BygSpopPdx1SpopPdx1tm1CvwSpopGtBGB118Byg
• abnormal pancreatic beta cell physiology_Pdx1<tm1Cvw>/Pdx1<+>
  http://metadb.riken.jp/0003562I129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1Pdx1Pdx1tm1Cvw
• decreased pancreatic beta cell number_Pdx1<tm1Cvw>/Pdx1<+>
  http://metadb.riken.jp/0003339I129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1Pdx1Pdx1tm1Cvw
• abnormal pancreatic beta cell morphology_Pdx1<tm1Cvw>/Pdx1<+>,Spop<Gt(BGB118)Byg>/Spop<+>
  http://metadb.riken.jp/0005217I129P2OlaHsd129S1Sv129X1SvJC57BL6Pdx1tm1CvwPdx1SpopGtBGB118BygSpopPdx1SpopPdx1tm1CvwSpopGtBGB118Byg

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD14255
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD14255
• CD02030
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02030