John S. Welch, et.al., PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice., The Journal of clinical investigation, 2011, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/21364283

John S. Welch, et.al., PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice., The Journal of clinical investigation, 2011, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Pml<tm1(PML/RARA)Ley>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5014059

class

http://purl.org/net/cito/citesAsAuthority

• Pml<tm1(PML/RARA)Ley>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5014059

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased hematopoietic stem cell number_Pml<tm1(PML/RARA)Ley>/Pml<+>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0004810IBALBcJC57BL6CBAPmltm1PMLRARALeyPmlTgCAGcreEsr15Amc0TgCAGcreEsr15AmcPmltm1PMLRARALeyPml
• no abnormal phenotype detected_Pml<tm1(PML/RARA)Ley>/Pml<+>
  http://metadb.riken.jp/0002169IC57BL6Pmltm1PMLRARALeyPmlPmltm1PMLRARALeyPml
• increased leukemia incidence_Pml<tm1(PML/RARA)Ley>/Pml<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002026I129P2OlaHsdBALBcJC57BL6Pmltm1PMLRARALeyPmlLyz2tm1creIfoLyz2Lyz2PmlLyz2tm1creIfoPmltm1PMLRARALey
• enlarged spleen_Pml<tm1(PML/RARA)Ley>/Pml<+>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0000691IBALBcJC57BL6CBAPmltm1PMLRARALeyPmlTgCAGcreEsr15Amc0TgCAGcreEsr15AmcPmltm1PMLRARALeyPml
• enlarged spleen_Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6Lyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfo
• abnormal hematopoietic stem cell physiology_Pml<tm1(PML/RARA)Ley>/Pml<+>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0010763IBALBcJC57BL6CBAPmltm1PMLRARALeyPmlTgCAGcreEsr15Amc0TgCAGcreEsr15AmcPmltm1PMLRARALeyPml
• prenatal lethality, complete penetrance_Pml<tm1(PML/RARA)Ley>/Pml<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0011091IC57BL6CBAPmltm1PMLRARALeyPmlTgMx1cre1Cgn0TgMx1cre1CgnPmlPmltm1PMLRARALey
• prenatal lethality, complete penetrance_Pml<tm1(PML/RARA)Ley>/Pml<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0011091IBALBcJC57BL6Pmltm1PMLRARALeyPmlTgCMVcre1Cgn0Pmltm1PMLRARALeyPmlTgCMVcre1Cgn

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged spleen in RBRC02303
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1004122
• enlarged spleen in RBRC02302
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1004121