William J. Kaiser, et.al., RIP3 mediates the embryonic lethality of caspase-8-deficient mice., Nature, 2011, 471

http://rdf.ncbi.nlm.nih.gov/pubmed/21368762

William J. Kaiser, et.al., RIP3 mediates the embryonic lethality of caspase-8-deficient mice., Nature, 2011, 471

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased leukocyte cell number_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0000218I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• abnormal liver physiology_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0000609I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• enlarged spleen_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0000691I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• wavy neural tube_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>
  http://metadb.riken.jp/0000930I129P2OlaHsdCasp8tm11RazCasp8tm11RazCasp8tm11Raz
• embryonic growth arrest_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<+>
  http://metadb.riken.jp/0001730I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3Ripk3tm1VmdRipk3Casp8tm11Raz
• increased inflammatory response_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0001846I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
他14件を見る
• abnormal blood circulation_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>
  http://metadb.riken.jp/0002128I129P2OlaHsdCasp8tm11RazCasp8tm11RazCasp8tm11Raz
• abnormal macrophage physiology_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0002451I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• abnormal vitelline vasculature morphology_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<+>
  http://metadb.riken.jp/0003229I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3Ripk3tm1VmdRipk3Casp8tm11Raz
• abnormal vitelline vasculature morphology_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>
  http://metadb.riken.jp/0003229I129P2OlaHsdCasp8tm11RazCasp8tm11RazCasp8tm11Raz
• increased B cell number_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0005014I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• increased T cell number_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0005015I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• lymph node hyperplasia_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0008102I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• increased spleen white pulp amount_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0008478I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• enlarged cervical lymph nodes_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0008542I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• enlarged axillary lymph nodes_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0009631I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• decreased macrophage apoptosis_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<tm1Vmd>
  http://metadb.riken.jp/0011081I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3tm1VmdRipk3tm1VmdCasp8tm11Raz
• embryonic lethality, complete penetrance_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<+>
  http://metadb.riken.jp/0011092I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3Ripk3tm1VmdRipk3Casp8tm11Raz
• embryonic lethality, complete penetrance_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>
  http://metadb.riken.jp/0011092I129P2OlaHsdCasp8tm11RazCasp8tm11RazCasp8tm11Raz
• abnormal visceral yolk sac blood island morphology_Casp8<tm1.1Raz>/Casp8<tm1.1Raz>,Ripk3<tm1Vmd>/Ripk3<+>
  http://metadb.riken.jp/0011204I129P2OlaHsd129S1Sv129X1SvJCasp8tm11RazCasp8tm11RazRipk3tm1VmdRipk3Ripk3tm1VmdRipk3Casp8tm11Raz