Charbel. Darido, et.al., Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis., Cancer cell, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/22094257

Charbel. Darido, et.al., Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis., Cancer cell, 2011, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Grhl3<tm3.1Jane>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5306651

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased tumor incidence_Grhl3<tm1Jane>/Grhl3<tm3.1Jane>,Tg(MMTV-cre)4Mam/0
  http://metadb.riken.jp/0002020I129S1SvC57BL6FVBGrhl3tm1JaneGrhl3tm31JaneTgMMTVcre4Mam0TgMMTVcre4MamGrhl3tm1JaneGrhl3tm31Jane
• increased skin squamous cell carcinoma incidence_Grhl3<tm1Jane>/Grhl3<+>,Pten<tm1Mak>/Pten<+>
  http://metadb.riken.jp/0009704I129P2OlaHsd129S1SvGrhl3tm1JaneGrhl3Ptentm1MakPtenPtentm1MakGrhl3Grhl3tm1JanePten
• abnormal skin physiology_Grhl3<tm1Jane>/Grhl3<tm3.1Jane>,Tg(MMTV-cre)4Mam/0
  http://metadb.riken.jp/0005501I129S1SvC57BL6FVBGrhl3tm1JaneGrhl3tm31JaneTgMMTVcre4Mam0TgMMTVcre4MamGrhl3tm1JaneGrhl3tm31Jane
• epidermal hyperplasia_Grhl3<tm1Jane>/Grhl3<tm3.1Jane>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0001222I129S1SvC57BL6FVBNGrhl3tm1JaneGrhl3tm31JaneTgKRT14cre8Brn0Grhl3tm31JaneTgKRT14cre8BrnGrhl3tm1Jane
• no abnormal phenotype detected_Grhl3<tm3.1Jane>/Grhl3<tm3.1Jane>
  http://metadb.riken.jp/0002169I129S1SvC57BL6Grhl3tm31JaneGrhl3tm31JaneGrhl3tm31Jane
• increased incidence of tumors by chemical induction_Grhl3<tm1Jane>/Grhl3<tm3.1Jane>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0004499I129S1SvC57BL6FVBNGrhl3tm1JaneGrhl3tm31JaneTgKRT14cre8Brn0Grhl3tm31JaneTgKRT14cre8BrnGrhl3tm1Jane
• increased skin squamous cell carcinoma incidence_Grhl3<tm1Jane>/Grhl3<tm3.1Jane>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0009704I129S1SvC57BL6FVBNGrhl3tm1JaneGrhl3tm31JaneTgKRT14cre8Brn0Grhl3tm31JaneTgKRT14cre8BrnGrhl3tm1Jane
• thick epidermis_Grhl3<tm1Jane>/Grhl3<tm1Jane>
  http://metadb.riken.jp/0001219I129S1SvGrhl3tm1JaneGrhl3tm1JaneGrhl3tm1Jane
• increased skin papilloma incidence_Grhl3<tm1Jane>/Grhl3<+>,Pten<tm1Mak>/Pten<+>
  http://metadb.riken.jp/0002051I129P2OlaHsd129S1SvGrhl3tm1JaneGrhl3Ptentm1MakPtenPtentm1MakGrhl3Grhl3tm1JanePten
• abnormal skin morphology_Grhl3<tm1Jane>/Grhl3<tm3.1Jane>,Tg(MMTV-cre)4Mam/0
  http://metadb.riken.jp/0002060I129S1SvC57BL6FVBGrhl3tm1JaneGrhl3tm31JaneTgMMTVcre4Mam0TgMMTVcre4MamGrhl3tm1JaneGrhl3tm31Jane
• increased skin papilloma incidence_Grhl3<tm1Jane>/Grhl3<tm3.1Jane>,Tg(KRT14-cre)8Brn/0
  http://metadb.riken.jp/0002051I129S1SvC57BL6FVBNGrhl3tm1JaneGrhl3tm31JaneTgKRT14cre8Brn0Grhl3tm31JaneTgKRT14cre8BrnGrhl3tm1Jane
• increased keratinocyte proliferation_Grhl3<tm1Jane>/Grhl3<tm1Jane>
  http://metadb.riken.jp/0009583I129S1SvGrhl3tm1JaneGrhl3tm1JaneGrhl3tm1Jane

class

http://purl.org/net/cito/citesAsAuthority

• Grhl3<tm3.1Jane>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5306651