Shengli. Xu, et.al., The RNase III enzyme Dicer is essential for germinal center B-cell formation., Blood, 2012, 119

http://rdf.ncbi.nlm.nih.gov/pubmed/22117047

Shengli. Xu, et.al., The RNase III enzyme Dicer is essential for germinal center B-cell formation., Blood, 2012, 119

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Aicda<tm1(cre)Njen>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5314932

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• absent plasma cells_Aicda<tm1(cre)Njen>/Aicda<+>,Dicer1<tm1Bdh>/Dicer1<tm1Bdh>
  http://metadb.riken.jp/0008100I129C57BL6Aicdatm1creNjenAicdaDicer1tm1BdhDicer1tm1BdhAicdaAicdatm1creNjenDicer1tm1Bdh
• decreased germinal center B cell number_Aicda<tm1(cre)Njen>/Aicda<+>,Bcl2l11<tm1Ast>/Bcl2l11<tm1Ast>,Dicer1<tm1Bdh>/Dicer1<tm1Bdh>
  http://metadb.riken.jp/0008178I129S1SvC57BL6Aicdatm1creNjenAicdaBcl2l11tm1AstBcl2l11tm1AstDicer1tm1BdhDicer1tm1BdhAicdaAicdatm1creNjenDicer1tm1BdhBcl2l11tm1Ast
• abnormal B cell differentiation_Aicda<tm1(cre)Njen>/Aicda<+>,Bcl2l11<tm1Ast>/Bcl2l11<tm1Ast>,Dicer1<tm1Bdh>/Dicer1<tm1Bdh>
  http://metadb.riken.jp/0002144I129S1SvC57BL6Aicdatm1creNjenAicdaBcl2l11tm1AstBcl2l11tm1AstDicer1tm1BdhDicer1tm1BdhAicdaAicdatm1creNjenDicer1tm1BdhBcl2l11tm1Ast
• decreased germinal center B cell number_Aicda<tm1(cre)Njen>/Aicda<+>,Dicer1<tm1Bdh>/Dicer1<tm1Bdh>
  http://metadb.riken.jp/0008178I129C57BL6Aicdatm1creNjenAicdaDicer1tm1BdhDicer1tm1BdhAicdaAicdatm1creNjenDicer1tm1Bdh
• abnormal germinal center B cell physiology_Aicda<tm1(cre)Njen>/Aicda<+>,Dicer1<tm1Bdh>/Dicer1<tm1Bdh>
  http://metadb.riken.jp/0008192I129C57BL6Aicdatm1creNjenAicdaDicer1tm1BdhDicer1tm1BdhAicdaAicdatm1creNjenDicer1tm1Bdh
• decreased immunoglobulin level_Aicda<tm1(cre)Njen>/Aicda<+>,Dicer1<tm1Bdh>/Dicer1<tm1Bdh>
  http://metadb.riken.jp/0002460I129C57BL6Aicdatm1creNjenAicdaDicer1tm1BdhDicer1tm1BdhAicdaAicdatm1creNjenDicer1tm1Bdh
• abnormal humoral immune response_Aicda<tm1(cre)Njen>/Aicda<+>,Dicer1<tm1Bdh>/Dicer1<tm1Bdh>
  http://metadb.riken.jp/0001800I129C57BL6Aicdatm1creNjenAicdaDicer1tm1BdhDicer1tm1BdhAicdaAicdatm1creNjenDicer1tm1Bdh
• decreased plasma cell number_Aicda<tm1(cre)Njen>/Aicda<+>,Bcl2l11<tm1Ast>/Bcl2l11<tm1Ast>,Dicer1<tm1Bdh>/Dicer1<tm1Bdh>
  http://metadb.riken.jp/0008098I129S1SvC57BL6Aicdatm1creNjenAicdaBcl2l11tm1AstBcl2l11tm1AstDicer1tm1BdhDicer1tm1BdhAicdaAicdatm1creNjenDicer1tm1BdhBcl2l11tm1Ast
• absent memory B cells_Aicda<tm1(cre)Njen>/Aicda<+>,Dicer1<tm1Bdh>/Dicer1<tm1Bdh>
  http://metadb.riken.jp/0008094I129C57BL6Aicdatm1creNjenAicdaDicer1tm1BdhDicer1tm1BdhAicdaAicdatm1creNjenDicer1tm1Bdh

class

http://purl.org/net/cito/citesAsAuthority

• Aicda<tm1(cre)Njen>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5314932