F. Bai, et.al., Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation., Oncogene, 2013, 32

http://rdf.ncbi.nlm.nih.gov/pubmed/22777348

F. Bai, et.al., Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation., Oncogene, 2013, 32

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased body weight_Brca1<tm1Bhk>/Brca1<+>
  http://metadb.riken.jp/0001262C129P2Brca1tm1BhkBrca1tm1BhkBrca1Brca1Brca1tm1Bhk
• decreased mammary gland epithelial cell proliferation_Brca1<tm1Bhk>/Brca1<+>
  http://metadb.riken.jp/0010174C129P2Brca1tm1BhkBrca1tm1BhkBrca1Brca1Brca1tm1Bhk
• increased mammary adenocarcinoma incidence_Brca1<tm1Bhk>/Brca1<+>,Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>
  http://metadb.riken.jp/0001883C129Cdkn2ctm1YxiBrca1tm1BhkBrca1tm1BhkBrca1Cdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1YxiBrca1tm1BhkBrca1
• abnormal mammary gland morphology_Brca1<tm1Bhk>/Brca1<+>,Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>
  http://metadb.riken.jp/0000627C129Cdkn2ctm1YxiBrca1tm1BhkBrca1tm1BhkBrca1Cdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1YxiBrca1tm1BhkBrca1
• lethality throughout fetal growth and development, complete penetrance_Brca1<tm1Bhk>/Brca1<tm1Bhk>,Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>
  http://metadb.riken.jp/0011099C129Cdkn2ctm1YxiBrca1tm1BhkBrca1tm1BhkBrca1tm1BhkCdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1YxiBrca1tm1Bhk
• early cellular replicative senescence_Brca1<tm1Bhk>/Brca1<+>
  http://metadb.riken.jp/0008008C129P2Brca1tm1BhkBrca1tm1BhkBrca1Brca1Brca1tm1Bhk
• increased mammary gland tumor incidence_Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>
  http://metadb.riken.jp/0010299C129Cdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1Yxi
• increased mammary gland tumor incidence_Brca1<tm1Bhk>/Brca1<+>,Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>
  http://metadb.riken.jp/0010299C129Cdkn2ctm1YxiBrca1tm1BhkBrca1tm1BhkBrca1Cdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1YxiBrca1tm1BhkBrca1
• abnormal mammary gland morphology_Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>
  http://metadb.riken.jp/0000627C129Cdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1Yxi
• increased mammary gland tumor incidence_Brca1<tm1Bhk>/Brca1<+>
  http://metadb.riken.jp/0010299C129P2Brca1tm1BhkBrca1tm1BhkBrca1Brca1Brca1tm1Bhk
• increased metastatic potential_Brca1<tm1Bhk>/Brca1<+>,Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>
  http://metadb.riken.jp/0001272C129Cdkn2ctm1YxiBrca1tm1BhkBrca1tm1BhkBrca1Cdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1YxiBrca1tm1BhkBrca1