Jacqueline A. Quandt, et.al., Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis., Journal of immunology (Baltimore, Md. : 1950), 2012, 189

http://rdf.ncbi.nlm.nih.gov/pubmed/22888134

Jacqueline A. Quandt, et.al., Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis., Journal of immunology (Baltimore, Md. : 1950), 2012, 189

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(HLA-DRA,HLA-DRB5*0101)loKito
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635431
• Tg(HLA-DRA,HLA-DRB5*0101)hiKito
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635424
• Tg(TRATL3A6,TRBTL3A6)#Kito
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635436

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• brain inflammation_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(HLA-DRA,HLA-DRB5*0101)loKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0001847I129S2SvPas129S7SvEvBrdC57BL6H2dlAb1EaH2dlAb1EaRag1tm1MomRag1tm1MomTgHLADRAHLADRB50101loKito0TgTRATL3A6TRBTL3A6Kito0TgTRATL3A6TRBTL3A6KitoTgHLADRAHLADRB50101loKitoH2dlAb1EaRag1tm1Mom
• brain inflammation_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)loKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0001847I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101loKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgTRATL3A6TRBTL3A6KitoTgHLADRAHLADRB50101loKito
• increased interferon-gamma secretion_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0008566I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• increased CD4-positive, alpha beta T cell number_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0008074I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• abnormal cytokine secretion_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0003009I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• increased inflammatory response_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0001846I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• increased T-helper 17 cell number_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0010219I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• increased susceptibility to experimental autoimmune encephalomyelitis_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)loKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0004799I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101loKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgTRATL3A6TRBTL3A6KitoTgHLADRAHLADRB50101loKito
• CNS inflammation_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0006082I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• brain inflammation_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0001847I129S2SvPas129S7SvEvBrdC57BL6H2dlAb1EaH2dlAb1EaRag1tm1MomRag1tm1MomTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0TgTRATL3A6TRBTL3A6KitoTgHLADRAHLADRB50101hiKitoRag1tm1MomH2dlAb1Ea
• neuron degeneration_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0003224I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• brain inflammation_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0001847I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• increased interleukin-17 secretion_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0008681I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• increased susceptibility to experimental autoimmune encephalomyelitis_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0004799I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• increased T-helper 1 cell number_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0008086I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• abnormal motor capabilities/coordination/movement_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0002066I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• axon degeneration_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0005405I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito
• abnormal axon morphology_H2<dlAb1-Ea>/H2<dlAb1-Ea>,Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0
  http://metadb.riken.jp/0005404I129S2SvPasC57BL6H2dlAb1EaH2dlAb1EaTgHLADRAHLADRB50101hiKito0TgTRATL3A6TRBTL3A6Kito0H2dlAb1EaTgHLADRAHLADRB50101hiKitoTgTRATL3A6TRBTL3A6Kito

class

http://purl.org/net/cito/citesAsAuthority

• Tg(HLA-DRA,HLA-DRB5*0101)loKito
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635431
• Tg(HLA-DRA,HLA-DRB5*0101)hiKito
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635424
• Tg(TRATL3A6,TRBTL3A6)#Kito
  http://metadb.riken.jp/db/mgi_rdf/MGI:5635436