Zhenyi. Liu, et.al., The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development., Developmental cell, 2013, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/23806616

Zhenyi. Liu, et.al., The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development., Developmental cell, 2013, 25

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Notch2<tm3.1Rko>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5523517
• Notch1<tm6.1Rko>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5523515

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• renal hypoplasia_Notch1<tm6.1Rko>/Notch1<+>,Notch2<tm3Grid>/Notch2<tm3Grid>,Tg(Pax3-cre)1Joe/0
  http://metadb.riken.jp/0003446I129S1SvC57BL6SJLNotch1tm61RkoNotch1Notch2tm3GridNotch2tm3GridTgPax3cre1Joe0Notch2tm3GridNotch1TgPax3cre1JoeNotch1tm61Rko
• renal hypoplasia_Notch1<tm6.1Rko>/Notch1<tm6.1Rko>,Notch2<tm3Grid>/Notch2<tm3Grid>,Tg(Pax3-cre)1Joe/0
  http://metadb.riken.jp/0003446I129S1SvC57BL6SJLNotch1tm61RkoNotch1tm61RkoNotch2tm3GridNotch2tm3GridTgPax3cre1Joe0Notch2tm3GridTgPax3cre1JoeNotch1tm61Rko
• abnormal nephron morphogenesis_Dll1<tm1Mjo>/Dll1<tm1Mjo>,Jag1<tm1Frad>/Jag1<+>,Tg(Six2-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0012024I129SvC57BL6CD1Dll1tm1MjoDll1tm1MjoJag1tm1FradJag1TgSix2EGFPcre1Amc0Dll1tm1MjoTgSix2EGFPcre1AmcJag1Jag1tm1Frad
• neonatal lethality, complete penetrance_Notch1<tm6.1Rko>/Notch1<tm6.1Rko>,Notch2<tm3Grid>/Notch2<tm3Grid>,Tg(Pax3-cre)1Joe/0
  http://metadb.riken.jp/0011087I129S1SvC57BL6SJLNotch1tm61RkoNotch1tm61RkoNotch2tm3GridNotch2tm3GridTgPax3cre1Joe0Notch2tm3GridTgPax3cre1JoeNotch1tm61Rko
• decreased nephron number_Dll1<tm1Mjo>/Dll1<tm1Mjo>,Jag1<tm1Frad>/Jag1<+>,Tg(Six2-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0011290I129SvC57BL6CD1Dll1tm1MjoDll1tm1MjoJag1tm1FradJag1TgSix2EGFPcre1Amc0Dll1tm1MjoTgSix2EGFPcre1AmcJag1Jag1tm1Frad
• absent podocytes_Dll1<tm1Mjo>/Dll1<+>,Jag1<tm1Frad>/Jag1<tm1Frad>,Tg(Six2-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008137I129SvC57BL6CD1Dll1tm1MjoDll1Jag1tm1FradJag1tm1FradTgSix2EGFPcre1Amc0Dll1tm1MjoDll1TgSix2EGFPcre1AmcJag1tm1Frad
• neonatal lethality, complete penetrance_Notch2<tm3Grid>/Notch2<tm3Grid>,Tg(Pax3-cre)1Joe/0
  http://metadb.riken.jp/0011087I129S1SvC57BL6SJLNotch2tm3GridNotch2tm3GridTgPax3cre1Joe0TgPax3cre1JoeNotch2tm3Grid
• decreased nephron number_Jag1<tm1Frad>/Jag1<tm1Frad>,Tg(Six2-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0011290I129SvC57BL6CD1Jag1tm1FradJag1tm1FradTgSix2EGFPcre1Amc0TgSix2EGFPcre1AmcJag1tm1Frad
• renal hypoplasia_Notch2<tm3Grid>/Notch2<tm3Grid>,Tg(Pax3-cre)1Joe/0
  http://metadb.riken.jp/0003446I129S1SvC57BL6SJLNotch2tm3GridNotch2tm3GridTgPax3cre1Joe0TgPax3cre1JoeNotch2tm3Grid
• abnormal nephron morphogenesis_Dll1<tm1Mjo>/Dll1<tm1Mjo>,Tg(Six2-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0012024IC57BL6CD1Dll1tm1MjoDll1tm1MjoTgSix2EGFPcre1Amc0TgSix2EGFPcre1AmcDll1tm1Mjo
• decreased nephron number_Dll1<tm1Mjo>/Dll1<tm1Mjo>,Jag1<tm1Frad>/Jag1<tm1Frad>,Tg(Six2-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0011290I129SvC57BL6CD1Dll1tm1MjoDll1tm1MjoJag1tm1FradJag1tm1FradTgSix2EGFPcre1Amc0Dll1tm1MjoTgSix2EGFPcre1AmcJag1tm1Frad

class

http://purl.org/net/cito/citesAsAuthority

• Notch2<tm3.1Rko>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5523517
• Notch1<tm6.1Rko>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5523515