Cindy. Kunne, et.al., Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis., Laboratory investigation; a journal of technical methods and pathology, 2014, 94

http://rdf.ncbi.nlm.nih.gov/pubmed/25068656

Cindy. Kunne, et.al., Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis., Laboratory investigation; a journal of technical methods and pathology, 2014, 94

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• weight loss_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001263I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• increased bile salt level_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004789I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• increased hepatocyte proliferation_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003893I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor
• liver fibrosis_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003333I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor
• increased circulating bilirubin level_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005344I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor
• bile duct proliferation_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003255I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor
• abnormal bile salt homeostasis_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005365I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• increased liver weight_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002981I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• cholestasis_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000610I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• increased circulating bilirubin level_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005344I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• abnormal bile secretion_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004772I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• increased liver weight_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor
• abnormal bile salt homeostasis_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005365I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor
• increased circulating alkaline phosphatase level_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002968I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• increased sensitivity to induced morbidity/mortality_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0009763I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• increased bile salt level_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004789I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor
• cholestasis_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000610I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor
• increased circulating alanine transaminase level_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002941I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• bile duct proliferation_Atp8b1<tm1Nbf>/Atp8b1<tm1Nbf>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003255I129P2OlaHsd129S4SvJaeC57BL6DBAAtp8b1tm1NbfAtp8b1tm1NbfPortm1WolfPortm1WolfTgAlbcre21Mgn0Atp8b1tm1NbfPortm1WolfTgAlbcre21Mgn
• increased circulating alanine transaminase level_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002941I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor
• increased circulating alkaline phosphatase level_Abcb4<tm1Bor>/Abcb4<tm1Bor>,Por<tm1Wolf>/Por<tm1Wolf>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002968I129P2OlaHsdC57BL6DBAFVBNAbcb4tm1BorAbcb4tm1BorPortm1WolfPortm1WolfTgAlbcre21Mgn0Portm1WolfTgAlbcre21MgnAbcb4tm1Bor