Ying. Tian, et.al., A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice., Science translational medicine, 2015, 7

http://rdf.ncbi.nlm.nih.gov/pubmed/25787764

Ying. Tian, et.al., A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice., Science translational medicine, 2015, 7

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Mirc20<tm1.1Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792833
• Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792834

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged heart_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0000274I129S7SvEvBrdC57BL6GtROSA26Sortm11CAGMirc20EemGtROSA26SorNkx25tm1creRjsNkx25Nkx25tm1creRjsNkx25GtROSA26Sortm11CAGMirc20EemGtROSA26Sor
• abnormal myocardial fiber morphology_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/A1cf<+>
  http://metadb.riken.jp/0000278I129C57BL6FVBNGtROSA26Sortm11CAGMirc20EemGtROSA26SorA1cfTgMyh6creEsr11JmkA1cfA1cfTgMyh6creEsr11JmkA1cfGtROSA26SorGtROSA26Sortm11CAGMirc20Eem
• abnormal myocardial fiber morphology_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0000278I129S7SvEvBrdC57BL6GtROSA26Sortm11CAGMirc20EemGtROSA26SorNkx25tm1creRjsNkx25Nkx25tm1creRjsNkx25GtROSA26Sortm11CAGMirc20EemGtROSA26Sor
• altered response to myocardial infarction_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/A1cf<+>
  http://metadb.riken.jp/0000343I129C57BL6FVBNGtROSA26Sortm11CAGMirc20EemGtROSA26SorA1cfTgMyh6creEsr11JmkA1cfA1cfTgMyh6creEsr11JmkA1cfGtROSA26SorGtROSA26Sortm11CAGMirc20Eem
• premature death_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6GtROSA26Sortm11CAGMirc20EemGtROSA26SorNkx25tm1creRjsNkx25Nkx25tm1creRjsNkx25GtROSA26Sortm11CAGMirc20EemGtROSA26Sor
• increased heart weight_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/A1cf<+>
  http://metadb.riken.jp/0002833I129C57BL6FVBNGtROSA26Sortm11CAGMirc20EemGtROSA26SorA1cfTgMyh6creEsr11JmkA1cfA1cfTgMyh6creEsr11JmkA1cfGtROSA26SorGtROSA26Sortm11CAGMirc20Eem
他10件を見る
• increased heart weight_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0002833I129S7SvEvBrdC57BL6GtROSA26Sortm11CAGMirc20EemGtROSA26SorNkx25tm1creRjsNkx25Nkx25tm1creRjsNkx25GtROSA26Sortm11CAGMirc20EemGtROSA26Sor
• increased cardiomyocyte apoptosis_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0003222I129S7SvEvBrdC57BL6GtROSA26Sortm11CAGMirc20EemGtROSA26SorNkx25tm1creRjsNkx25Nkx25tm1creRjsNkx25GtROSA26Sortm11CAGMirc20EemGtROSA26Sor
• decreased cardiomyocyte apoptosis_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/A1cf<+>
  http://metadb.riken.jp/0003223I129C57BL6FVBNGtROSA26Sortm11CAGMirc20EemGtROSA26SorA1cfTgMyh6creEsr11JmkA1cfA1cfTgMyh6creEsr11JmkA1cfGtROSA26SorGtROSA26Sortm11CAGMirc20Eem
• abnormal myocardial fiber physiology_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/A1cf<+>
  http://metadb.riken.jp/0004215I129C57BL6FVBNGtROSA26Sortm11CAGMirc20EemGtROSA26SorA1cfTgMyh6creEsr11JmkA1cfA1cfTgMyh6creEsr11JmkA1cfGtROSA26SorGtROSA26Sortm11CAGMirc20Eem
• abnormal myocardial fiber physiology_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0004215I129S7SvEvBrdC57BL6GtROSA26Sortm11CAGMirc20EemGtROSA26SorNkx25tm1creRjsNkx25Nkx25tm1creRjsNkx25GtROSA26Sortm11CAGMirc20EemGtROSA26Sor
• small myocardial fiber_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/A1cf<+>
  http://metadb.riken.jp/0004565I129C57BL6FVBNGtROSA26Sortm11CAGMirc20EemGtROSA26SorA1cfTgMyh6creEsr11JmkA1cfA1cfTgMyh6creEsr11JmkA1cfGtROSA26SorGtROSA26Sortm11CAGMirc20Eem
• small myocardial fiber_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0004565I129S7SvEvBrdC57BL6GtROSA26Sortm11CAGMirc20EemGtROSA26SorNkx25tm1creRjsNkx25Nkx25tm1creRjsNkx25GtROSA26Sortm11CAGMirc20EemGtROSA26Sor
• decreased cardiac muscle contractility_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0005140I129S7SvEvBrdC57BL6GtROSA26Sortm11CAGMirc20EemGtROSA26SorNkx25tm1creRjsNkx25Nkx25tm1creRjsNkx25GtROSA26Sortm11CAGMirc20EemGtROSA26Sor
• increased myocardial fiber number_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/A1cf<+>
  http://metadb.riken.jp/0006321I129C57BL6FVBNGtROSA26Sortm11CAGMirc20EemGtROSA26SorA1cfTgMyh6creEsr11JmkA1cfA1cfTgMyh6creEsr11JmkA1cfGtROSA26SorGtROSA26Sortm11CAGMirc20Eem
• increased fetal cardiomyocyte proliferation_Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>/Gt(ROSA)26Sor<+>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0011394I129S7SvEvBrdC57BL6GtROSA26Sortm11CAGMirc20EemGtROSA26SorNkx25tm1creRjsNkx25Nkx25tm1creRjsNkx25GtROSA26Sortm11CAGMirc20EemGtROSA26Sor

class

http://purl.org/net/cito/citesAsAuthority

• Mirc20<tm1.1Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792833
• Gt(ROSA)26Sor<tm1.1(CAG-Mirc20)Eem>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792834