T-L. Kuo, et.al., APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice., Oncogene, 2016, 35

http://rdf.ncbi.nlm.nih.gov/pubmed/26411367

T-L. Kuo, et.al., APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice., Oncogene, 2016, 35

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Apc<tm2Rak>/Apc<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0002083I129Sv129P2OlaHsdC57BL6JFVBNSJLApctm2RakApcTrp53tm1BrnTrp53tm1BrnTgPdx1cre6Tuv0Apctm2RakApcTrp53tm1BrnTgPdx1cre6Tuv
• abnormal pancreas development_Apc<tm2Rak>/Apc<tm2Rak>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0003934I129SvC57BL6JFVBNSJLApctm2RakApctm2RakTgPdx1cre6Tuv0TgPdx1cre6TuvApctm2Rak
• abnormal intestine development_Apc<tm2Rak>/Apc<tm2Rak>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0010158I129SvC57BL6JFVBNSJLApctm2RakApctm2RakTgPdx1cre6Tuv0TgPdx1cre6TuvApctm2Rak
• neonatal lethality, complete penetrance_Apc<tm2Rak>/Apc<tm2Rak>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0011087I129SvC57BL6JFVBNSJLApctm2RakApctm2RakTgPdx1cre6Tuv0TgPdx1cre6TuvApctm2Rak
• decreased pancreatic islet number_Apc<tm2Rak>/Apc<tm2Rak>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0009168I129SvC57BL6JFVBNSJLApctm2RakApctm2RakTgPdx1cre6Tuv0TgPdx1cre6TuvApctm2Rak
• increased circulating triglyceride level_Apc<tm2Rak>/Apc<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0001552I129Sv129P2OlaHsdC57BL6JFVBNSJLApctm2RakApcTrp53tm1BrnTrp53tm1BrnTgPdx1cre6Tuv0Apctm2RakApcTrp53tm1BrnTgPdx1cre6Tuv
• increased cystadenoma incidence_Apc<tm2Rak>/Apc<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0013751I129Sv129P2OlaHsdC57BL6JFVBNSJLApctm2RakApcTrp53tm1BrnTrp53tm1BrnTgPdx1cre6Tuv0Apctm2RakApcTrp53tm1BrnTgPdx1cre6Tuv
• increased pancreas tumor incidence_Apc<tm2Rak>/Apc<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0009153I129Sv129P2OlaHsdC57BL6JFVBNSJLApctm2RakApcTrp53tm1BrnTrp53tm1BrnTgPdx1cre6Tuv0Apctm2RakApcTrp53tm1BrnTgPdx1cre6Tuv
• increased circulating cholesterol level_Apc<tm2Rak>/Apc<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0005178I129Sv129P2OlaHsdC57BL6JFVBNSJLApctm2RakApcTrp53tm1BrnTrp53tm1BrnTgPdx1cre6Tuv0Apctm2RakApcTrp53tm1BrnTgPdx1cre6Tuv
• decreased pancreatic beta cell mass_Apc<tm2Rak>/Apc<tm2Rak>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0009114I129SvC57BL6JFVBNSJLApctm2RakApctm2RakTgPdx1cre6Tuv0TgPdx1cre6TuvApctm2Rak
• increased metastatic potential_Apc<tm2Rak>/Apc<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0001272I129Sv129P2OlaHsdC57BL6JFVBNSJLApctm2RakApcTrp53tm1BrnTrp53tm1BrnTgPdx1cre6Tuv0Apctm2RakApcTrp53tm1BrnTgPdx1cre6Tuv
• duodenal atresia_Apc<tm2Rak>/Apc<tm2Rak>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0003272I129SvC57BL6JFVBNSJLApctm2RakApctm2RakTgPdx1cre6Tuv0TgPdx1cre6TuvApctm2Rak
• abnormal cytokine level_Apc<tm2Rak>/Apc<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0008713I129Sv129P2OlaHsdC57BL6JFVBNSJLApctm2RakApcTrp53tm1BrnTrp53tm1BrnTgPdx1cre6Tuv0Apctm2RakApcTrp53tm1BrnTgPdx1cre6Tuv