Sumihiro. Maeda, et.al., Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice., EMBO reports, 2016, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/26931567

Sumihiro. Maeda, et.al., Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice., EMBO reports, 2016, 17

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-MAPT*A152T)L1Lms
  http://metadb.riken.jp/db/mgi_rdf/MGI:5788163
• Tg(tetO-MAPT)32Lms
  http://metadb.riken.jp/db/mgi_rdf/MGI:5788166

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hippocampal neuron degeneration_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0000811B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay
• decreased body weight_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT)32Lms/0
  http://metadb.riken.jp/0001262B6CgTgCamk2atTA1MmayTgtetOMAPT32LmsTgCamk2atTA1Mmay0TgtetOMAPT32Lms0TgtetOMAPT32LmsTgCamk2atTA1Mmay
• decreased body weight_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0001262B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay
• abnormal nest building behavior_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0001447B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay
• premature death_Tg(Camk2a-tTA)1Mmay/0,Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
  http://metadb.riken.jp/0002083IC57BL6C57BL6JDBA2TgCamk2atTA1Mmay0TgPDGFBAPPSwInd20Lms0TgtetOMAPT32Lms0TgCamk2atTA1MmayTgtetOMAPT32LmsTgPDGFBAPPSwInd20Lms
• abnormal brain morphology_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT)32Lms/0
  http://metadb.riken.jp/0002152B6CgTgCamk2atTA1MmayTgtetOMAPT32LmsTgCamk2atTA1Mmay0TgtetOMAPT32Lms0TgtetOMAPT32LmsTgCamk2atTA1Mmay
他17件を見る
• abnormal brain morphology_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0002152B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay
• abnormal CNS synaptic transmission_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT)32Lms/0
  http://metadb.riken.jp/0002206B6CgTgCamk2atTA1MmayTgtetOMAPT32LmsTgCamk2atTA1Mmay0TgtetOMAPT32Lms0TgtetOMAPT32LmsTgCamk2atTA1Mmay
• abnormal CNS synaptic transmission_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0002206B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay
• increased susceptibility to pharmacologically induced seizures_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT)32Lms/0
  http://metadb.riken.jp/0002906B6CgTgCamk2atTA1MmayTgtetOMAPT32LmsTgCamk2atTA1Mmay0TgtetOMAPT32Lms0TgtetOMAPT32LmsTgCamk2atTA1Mmay
• increased susceptibility to pharmacologically induced seizures_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0002906B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay
• decreased paired-pulse facilitation_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT)32Lms/0
  http://metadb.riken.jp/0002920B6CgTgCamk2atTA1MmayTgtetOMAPT32LmsTgCamk2atTA1Mmay0TgtetOMAPT32Lms0TgtetOMAPT32LmsTgCamk2atTA1Mmay
• decreased paired-pulse facilitation_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0002920B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay
• astrocytosis_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0003354B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay
• tau protein deposits_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0004250IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal brain wave pattern_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT)32Lms/0
  http://metadb.riken.jp/0004994B6CgTgCamk2atTA1MmayTgtetOMAPT32LmsTgCamk2atTA1Mmay0TgtetOMAPT32Lms0TgtetOMAPT32LmsTgCamk2atTA1Mmay
• abnormal brain wave pattern_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0004994B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay
• abnormal brain wave pattern_Tg(Camk2a-tTA)1Mmay/0,Tg(PDGFB-APPSwInd)J9Lms/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0004994IC57BL6C57BL6JDBA2TgCamk2atTA1Mmay0TgPDGFBAPPSwIndJ9Lms0TgtetOMAPTA152TL1Lms0TgCamk2atTA1MmayTgPDGFBAPPSwIndJ9LmsTgtetOMAPTA152TL1Lms
• lethality at weaning_Tg(Camk2a-tTA)1Mmay/0,Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0008569IC57BL6C57BL6JDBA2TgCamk2atTA1Mmay0TgPDGFBAPPSwInd20Lms0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgPDGFBAPPSwInd20LmsTgCamk2atTA1Mmay
• lethality, incomplete penetrance_Tg(Camk2a-tTA)1Mmay/0,Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT)32Lms/0
  http://metadb.riken.jp/0010831IC57BL6C57BL6JDBA2TgCamk2atTA1Mmay0TgPDGFBAPPSwInd20Lms0TgtetOMAPT32Lms0TgCamk2atTA1MmayTgtetOMAPT32LmsTgPDGFBAPPSwInd20Lms
• lethality, incomplete penetrance_Tg(Camk2a-tTA)1Mmay/0,Tg(PDGFB-APPSwInd)J9Lms/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0010831IC57BL6C57BL6JDBA2TgCamk2atTA1Mmay0TgPDGFBAPPSwIndJ9Lms0TgtetOMAPTA152TL1Lms0TgCamk2atTA1MmayTgPDGFBAPPSwIndJ9LmsTgtetOMAPTA152TL1Lms
• preweaning lethality, incomplete penetrance_Tg(Camk2a-tTA)1Mmay/0,Tg(PDGFB-APPSwInd)20Lms/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0011110IC57BL6C57BL6JDBA2TgCamk2atTA1Mmay0TgPDGFBAPPSwInd20Lms0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgPDGFBAPPSwInd20LmsTgCamk2atTA1Mmay
• impaired spatial learning_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-MAPT*A152T)L1Lms/0
  http://metadb.riken.jp/0012307B6CgTgCamk2atTA1MmayTgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay0TgtetOMAPTA152TL1Lms0TgtetOMAPTA152TL1LmsTgCamk2atTA1Mmay

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-MAPT*A152T)L1Lms
  http://metadb.riken.jp/db/mgi_rdf/MGI:5788163
• Tg(tetO-MAPT)32Lms
  http://metadb.riken.jp/db/mgi_rdf/MGI:5788166