Monica. Morales, et.al., The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor., Genes & development, 2005, 19

http://rdf.ncbi.nlm.nih.gov/pubmed/16357220

Monica. Morales, et.al., The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor., Genes & development, 2005, 19

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• chromosome breakage in RBRC02323
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1004196
• chromosome breakage in RBRC02774
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1005036

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cell cycle checkpoint function_Atm<tm1Awb>/Atm<tm1Awb>
  http://metadb.riken.jp/0004045I129S6SvEvTacC57BL6Atmtm1AwbAtmtm1AwbAtmtm1Awb
• decreased macrophage cell number_Chek2<tm1Mak>/Chek2<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0003884I129P2OlaHsd129S7SvEvBrdC57BL6Chek2tm1MakChek2Rad50tm2JptRad50tm2JptChek2tm1MakChek2Rad50tm2Jpt
• abnormal hematopoietic system morphology/development_Rad50<tm2Jpt>/Rad50<tm2Jpt>,Smc1a<tm1Mbk>/Smc1a<tm1Mbk>
  http://metadb.riken.jp/0002396I129S1Sv129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptSmc1atm1MbkSmc1atm1MbkRad50tm2JptSmc1atm1Mbk
• premature death_Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptRad50tm2Jpt
• decreased double-negative T cell number_Rad50<tm2Jpt>/Rad50<tm2Jpt>,Smc1a<tm1Mbk>/Smc1a<tm1Mbk>
  http://metadb.riken.jp/0005089I129S1Sv129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptSmc1atm1MbkSmc1atm1MbkRad50tm2JptSmc1atm1Mbk
• pancytopenia_Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0005152I129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptRad50tm2Jpt
• chromosome breakage_Atm<tm1Awb>/Atm<tm1Awb>
  http://metadb.riken.jp/0004028I129S6SvEvTacC57BL6Atmtm1AwbAtmtm1AwbAtmtm1Awb
• increased lymphoma incidence_Mre11a<tm1Jpt>/Mre11a<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6Mre11atm1JptMre11aRad50tm2JptRad50tm2JptMre11aMre11atm1JptRad50tm2Jpt
• premature death_Mre11a<tm1Jpt>/Mre11a<tm1Jpt>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6Mre11atm1JptMre11atm1JptRad50tm2JptRad50tm2JptRad50tm2JptMre11atm1Jpt
• abnormal cell cycle checkpoint function_Atm<tm1Awb>/Atm<tm1Awb>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0004045I129S6SvEvTac129S7SvEvBrdC57BL6Atmtm1AwbAtmtm1AwbRad50tm2JptRad50tm2JptAtmtm1AwbRad50tm2Jpt
• decreased pro-B cell number_Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0008208I129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptRad50tm2Jpt
• decreased macrophage cell number_Atm<tm1Awb>/Atm<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0003884I129S6SvEvTac129S7SvEvBrdC57BL6Atmtm1AwbAtmRad50tm2JptRad50tm2JptAtmRad50tm2JptAtmtm1Awb
• increased cellular sensitivity to ionizing radiation_Mre11a<tm1Jpt>/Mre11a<tm1Jpt>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0004227I129S7SvEvBrdC57BL6Mre11atm1JptMre11atm1JptRad50tm2JptRad50tm2JptRad50tm2JptMre11atm1Jpt
• decreased macrophage cell number_Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0003884I129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptRad50tm2Jpt
• premature death_Rad50<tm2Jpt>/Rad50<tm2Jpt>,Smc1a<tm1Mbk>/Smc1a<tm1Mbk>
  http://metadb.riken.jp/0002083I129S1Sv129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptSmc1atm1MbkSmc1atm1MbkRad50tm2JptSmc1atm1Mbk
• premature death_Rad50<tm1Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6Rad50tm1JptRad50tm2JptRad50tm1JptRad50tm2Jpt
• increased cellular sensitivity to ionizing radiation_Mre11a<tm1Jpt>/Mre11a<tm1Jpt>
  http://metadb.riken.jp/0004227I129S7SvEvBrdC57BL6Mre11atm1JptMre11atm1JptMre11atm1Jpt
• decreased double-negative T cell number_Chek2<tm1Mak>/Chek2<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0005089I129P2OlaHsd129S7SvEvBrdC57BL6Chek2tm1MakChek2Rad50tm2JptRad50tm2JptChek2tm1MakChek2Rad50tm2Jpt
• abnormal cell cycle checkpoint function_Mre11a<tm1Jpt>/Mre11a<tm1Jpt>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0004045I129S7SvEvBrdC57BL6Mre11atm1JptMre11atm1JptRad50tm2JptRad50tm2JptRad50tm2JptMre11atm1Jpt
• premature death_Atm<tm1Awb>/Atm<tm1Awb>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002083I129S6SvEvTac129S7SvEvBrdC57BL6Atmtm1AwbAtmtm1AwbRad50tm2JptRad50tm2JptAtmtm1AwbRad50tm2Jpt
• chromosome breakage_Atm<tm1Awb>/Atm<tm1Awb>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0004028I129S6SvEvTac129S7SvEvBrdC57BL6Atmtm1AwbAtmtm1AwbRad50tm2JptRad50tm2JptAtmtm1AwbRad50tm2Jpt
• anemia_Rad50<tm2Jpt>/Rad50<tm2Jpt>,Smc1a<tm1Mbk>/Smc1a<tm1Mbk>
  http://metadb.riken.jp/0001577I129S1Sv129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptSmc1atm1MbkSmc1atm1MbkRad50tm2JptSmc1atm1Mbk
• premature death_Mre11a<tm1Jpt>/Mre11a<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6Mre11atm1JptMre11aRad50tm2JptRad50tm2JptMre11aMre11atm1JptRad50tm2Jpt
• increased lymphoma incidence_Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptRad50tm2Jpt
• chromosome breakage_Mre11a<tm1Jpt>/Mre11a<tm1Jpt>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0004028I129S7SvEvBrdC57BL6Mre11atm1JptMre11atm1JptRad50tm2JptRad50tm2JptRad50tm2JptMre11atm1Jpt
• anemia_Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0001577I129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptRad50tm2Jpt
• premature death_Chek2<tm1Mak>/Chek2<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S7SvEvBrdC57BL6Chek2tm1MakChek2Rad50tm2JptRad50tm2JptChek2tm1MakChek2Rad50tm2Jpt
• abnormal hematopoietic system morphology/development_Mre11a<tm1Jpt>/Mre11a<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002396I129S7SvEvBrdC57BL6Mre11atm1JptMre11aRad50tm2JptRad50tm2JptMre11aMre11atm1JptRad50tm2Jpt
• anemia_Rad50<tm2Jpt>/Rad50<tm2Jpt>,Tg(BCL2)22Wehi/0
  http://metadb.riken.jp/0001577I129S7SvEvBrdC57BL6C57BL6JWehiSJLJWehiRad50tm2JptRad50tm2JptTgBCL222Wehi0Rad50tm2JptTgBCL222Wehi
• increased lymphoma incidence_Chek2<tm1Mak>/Chek2<tm1Mak>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0012431I129P2OlaHsd129S7SvEvBrdC57BL6Chek2tm1MakChek2tm1MakRad50tm2JptRad50tm2JptRad50tm2JptChek2tm1Mak
• abnormal pro-B cell morphology_Chek2<tm1Mak>/Chek2<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0005432I129P2OlaHsd129S7SvEvBrdC57BL6Chek2tm1MakChek2Rad50tm2JptRad50tm2JptChek2tm1MakChek2Rad50tm2Jpt
• increased lymphoma incidence_Atm<tm1Awb>/Atm<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0012431I129S6SvEvTac129S7SvEvBrdC57BL6Atmtm1AwbAtmRad50tm2JptRad50tm2JptAtmRad50tm2JptAtmtm1Awb
• decreased double-negative T cell number_Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0005089I129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptRad50tm2Jpt
• premature death_Rad50<tm2Jpt>/Rad50<tm2Jpt>,Tg(BCL2)22Wehi/0
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6C57BL6JWehiSJLJWehiRad50tm2JptRad50tm2JptTgBCL222Wehi0Rad50tm2JptTgBCL222Wehi
• abnormal pro-B cell morphology_Rad50<tm2Jpt>/Rad50<tm2Jpt>,Smc1a<tm1Mbk>/Smc1a<tm1Mbk>
  http://metadb.riken.jp/0005432I129S1Sv129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptSmc1atm1MbkSmc1atm1MbkRad50tm2JptSmc1atm1Mbk
• abnormal hematopoietic system physiology_Rad50<tm1Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0001545I129S7SvEvBrdC57BL6Rad50tm1JptRad50tm2JptRad50tm1JptRad50tm2Jpt
• premature death_Atm<tm1Awb>/Atm<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002083I129S6SvEvTac129S7SvEvBrdC57BL6Atmtm1AwbAtmRad50tm2JptRad50tm2JptAtmRad50tm2JptAtmtm1Awb
• decreased macrophage cell number_Rad50<tm2Jpt>/Rad50<tm2Jpt>,Smc1a<tm1Mbk>/Smc1a<tm1Mbk>
  http://metadb.riken.jp/0003884I129S1Sv129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptSmc1atm1MbkSmc1atm1MbkRad50tm2JptSmc1atm1Mbk
• increased lymphoma incidence_Rad50<tm1Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6Rad50tm1JptRad50tm2JptRad50tm1JptRad50tm2Jpt
• increased T cell derived lymphoma incidence_Atm<tm1Awb>/Atm<tm1Awb>
  http://metadb.riken.jp/0002024I129S6SvEvTacC57BL6Atmtm1AwbAtmtm1AwbAtmtm1Awb
• anemia_Mre11a<tm1Jpt>/Mre11a<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0001577I129S7SvEvBrdC57BL6Mre11atm1JptMre11aRad50tm2JptRad50tm2JptMre11aMre11atm1JptRad50tm2Jpt
• increased lymphoma incidence_Atm<tm1Awb>/Atm<tm1Awb>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0012431I129S6SvEvTac129S7SvEvBrdC57BL6Atmtm1AwbAtmtm1AwbRad50tm2JptRad50tm2JptAtmtm1AwbRad50tm2Jpt
• abnormal cell cycle checkpoint function_Mre11a<tm1Jpt>/Mre11a<tm1Jpt>
  http://metadb.riken.jp/0004045I129S7SvEvBrdC57BL6Mre11atm1JptMre11atm1JptMre11atm1Jpt
• abnormal bone marrow cell morphology/development_Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002398I129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptRad50tm2Jpt
• premature death_Atm<tm1Awb>/Atm<tm1Awb>
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6Atmtm1AwbAtmtm1AwbAtmtm1Awb
• anemia_Rad50<tm1Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0001577I129S7SvEvBrdC57BL6Rad50tm1JptRad50tm2JptRad50tm1JptRad50tm2Jpt
• anemia_Chek2<tm1Mak>/Chek2<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0001577I129P2OlaHsd129S7SvEvBrdC57BL6Chek2tm1MakChek2Rad50tm2JptRad50tm2JptChek2tm1MakChek2Rad50tm2Jpt
• thrombocytopenia_Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0003179I129S7SvEvBrdC57BL6Rad50tm2JptRad50tm2JptRad50tm2Jpt
• increased lymphoma incidence_Mre11a<tm1Jpt>/Mre11a<tm1Jpt>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6Mre11atm1JptMre11atm1JptRad50tm2JptRad50tm2JptRad50tm2JptMre11atm1Jpt
• chromosome breakage_Mre11a<tm1Jpt>/Mre11a<tm1Jpt>
  http://metadb.riken.jp/0004028I129S7SvEvBrdC57BL6Mre11atm1JptMre11atm1JptMre11atm1Jpt
• premature death_Chek2<tm1Mak>/Chek2<tm1Mak>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S7SvEvBrdC57BL6Chek2tm1MakChek2tm1MakRad50tm2JptRad50tm2JptRad50tm2JptChek2tm1Mak
• anemia_Atm<tm1Awb>/Atm<tm1Awb>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0001577I129S6SvEvTac129S7SvEvBrdC57BL6Atmtm1AwbAtmtm1AwbRad50tm2JptRad50tm2JptAtmtm1AwbRad50tm2Jpt
• anemia_Atm<tm1Awb>/Atm<+>,Rad50<tm2Jpt>/Rad50<tm2Jpt>
  http://metadb.riken.jp/0001577I129S6SvEvTac129S7SvEvBrdC57BL6Atmtm1AwbAtmRad50tm2JptRad50tm2JptAtmRad50tm2JptAtmtm1Awb