Xin. Ye, et.al., Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization., Cell, 2009, 139

http://rdf.ncbi.nlm.nih.gov/pubmed/19837032

Xin. Ye, et.al., Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization., Cell, 2009, 139

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD12277
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12277
• CD28725
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD28725

allele

http://purl.org/net/cito/citesAsAuthority

• Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4412094
• Ndp<tm2Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4414794
• Ndp<tm1.1Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4412060
• Fzd4<tm2.1Nat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4412057

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal retinal vasculature morphology_Fzd4<tm1Nat>/Fzd4<tm1Nat>
  http://metadb.riken.jp/0002792I129S1Sv129X1SvJFzd4tm1NatFzd4tm1NatFzd4tm1Nat
• abnormal eye electrophysiology_Fzd4<tm1Nat>/Fzd4<tm1Nat>
  http://metadb.riken.jp/0005551I129S1Sv129X1SvJFzd4tm1NatFzd4tm1NatFzd4tm1Nat
• abnormal brain vasculature morphology_Fzd4<tm1Nat>/Fzd4<tm1Nat>
  http://metadb.riken.jp/0004950I129S1Sv129X1SvJFzd4tm1NatFzd4tm1NatFzd4tm1Nat
• abnormal optokinetic reflex_Fzd4<tm1Nat>/Fzd4<tm1Nat>
  http://metadb.riken.jp/0009619I129S1Sv129X1SvJFzd4tm1NatFzd4tm1NatFzd4tm1Nat
• no abnormal phenotype detected_Fzd4<tm2.1Nat>/Fzd4<tm2.1Nat>
  http://metadb.riken.jp/0002169I129S1Sv129X1SvJFzd4tm21NatFzd4tm21NatFzd4tm21Nat
• abnormal angiogenesis_Lrp5<tm1Kry>/Lrp5<tm1Kry>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0000260I129C57BL6CBALrp5tm1KryLrp5tm1KryIgs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcLrp5tm1Kry
• abnormal optokinetic reflex_Fzd4<tm1Nat>/Fzd4<tm2.1Nat>,Tg(Tek-cre)1Ywa/?
  http://metadb.riken.jp/0009619I129S1Sv129X1SvJC57BL6SJLFzd4tm1NatFzd4tm21NatTgTekcre1YwaFzd4tm1NatTgTekcre1YwaFzd4tm21Nat
• abnormal retinal vasculature morphology_Fzd4<tm1Nat>/Fzd4<tm2.1Nat>,Tg(Tek-cre)1Ywa/?
  http://metadb.riken.jp/0002792I129S1Sv129X1SvJC57BL6SJLFzd4tm1NatFzd4tm21NatTgTekcre1YwaFzd4tm1NatTgTekcre1YwaFzd4tm21Nat
• abnormal aorta smooth muscle morphology_Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0009865I129C57BL6CBAIgs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1Amc
• abnormal angiogenesis_Fzd4<tm1Nat>/Fzd4<+>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0000260I129C57BL6CBAFzd4tm1NatFzd4Igs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcFzd4tm1NatFzd4
• abnormal angiogenesis_Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0000260I129C57BL6CBAIgs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1Amc
• abnormal eye electrophysiology_Fzd4<tm1Nat>/Fzd4<tm2.1Nat>,Tg(rx3-icre)1Mjam/?
  http://metadb.riken.jp/0005551I129S1Sv129X1SvJFzd4tm1NatFzd4tm21NatTgrx3icre1MjamFzd4tm21NatTgrx3icre1MjamFzd4tm1Nat
• abnormal descending aorta morphology_Lrp5<tm1Kry>/Lrp5<tm1Kry>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0009869I129C57BL6CBALrp5tm1KryLrp5tm1KryIgs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcLrp5tm1Kry
• abnormal retinal vasculature morphology_Ndp<tm2Nat>/Ndp<+>
  http://metadb.riken.jp/0002792I129S1Sv129X1SvJC57BL6Ndptm2NatNdpNdptm2NatNdp
• abnormal descending aorta morphology_Fzd4<tm1Nat>/Fzd4<+>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0009869I129C57BL6CBAFzd4tm1NatFzd4Igs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcFzd4tm1NatFzd4
• embryonic growth retardation_Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0003984I129C57BL6CBAIgs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1Amc
• embryonic growth retardation_Fzd4<tm1Nat>/Fzd4<+>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0003984I129C57BL6CBAFzd4tm1NatFzd4Igs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcFzd4tm1NatFzd4
• embryonic lethality, incomplete penetrance_Fzd4<tm1Nat>/Fzd4<+>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0011102I129C57BL6CBAFzd4tm1NatFzd4Igs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcFzd4tm1NatFzd4
• abnormal brain vasculature morphology_Ndp<tm2Nat>/Ndp<+>
  http://metadb.riken.jp/0004950I129S1Sv129X1SvJC57BL6Ndptm2NatNdpNdptm2NatNdp
• abnormal cerebellum morphology_Fzd4<tm1Nat>/Fzd4<tm1Nat>
  http://metadb.riken.jp/0000849I129S1Sv129X1SvJFzd4tm1NatFzd4tm1NatFzd4tm1Nat
• embryonic growth retardation_Lrp5<tm1Kry>/Lrp5<tm1Kry>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0003984I129C57BL6CBALrp5tm1KryLrp5tm1KryIgs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcLrp5tm1Kry
• prenatal lethality, complete penetrance_Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0011091I129C57BL6CBAIgs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1Amc
• impaired pupillary reflex_Fzd4<tm1Nat>/Fzd4<tm2.1Nat>,Tg(Tek-cre)1Ywa/?
  http://metadb.riken.jp/0006243I129S1Sv129X1SvJC57BL6SJLFzd4tm1NatFzd4tm21NatTgTekcre1YwaFzd4tm1NatTgTekcre1YwaFzd4tm21Nat
• embryonic lethality, incomplete penetrance_Lrp5<tm1Kry>/Lrp5<tm1Kry>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?
  http://metadb.riken.jp/0011102I129C57BL6CBALrp5tm1KryLrp5tm1KryIgs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcLrp5tm1Kry
• abnormal brain vasculature morphology_Fzd4<tm1Nat>/Fzd4<tm2.1Nat>,Tg(Tek-cre)1Ywa/?
  http://metadb.riken.jp/0004950I129S1Sv129X1SvJC57BL6SJLFzd4tm1NatFzd4tm21NatTgTekcre1YwaFzd4tm1NatTgTekcre1YwaFzd4tm21Nat
• abnormal eye electrophysiology_Fzd4<tm1Nat>/Fzd4<tm2.1Nat>,Tg(Tek-cre)1Ywa/?
  http://metadb.riken.jp/0005551I129S1Sv129X1SvJC57BL6SJLFzd4tm1NatFzd4tm21NatTgTekcre1YwaFzd4tm1NatTgTekcre1YwaFzd4tm21Nat
• impaired pupillary reflex_Fzd4<tm1Nat>/Fzd4<tm1Nat>
  http://metadb.riken.jp/0006243I129S1Sv129X1SvJFzd4tm1NatFzd4tm1NatFzd4tm1Nat