increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)89.1Dam/0

http://metadb.riken.jp/0009151I129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasTgPdx1cre891Dam0Cdkn2atm4RdpKrastm4TyjTgPdx1cre891DamKras

increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)89.1Dam/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 89.1, Douglas A Melton
  http://metadb.riken.jp/db/mgi_rdf/MGI:2684318
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)89.1Dam/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdkn2a<tm4Rdp>|Kras<tm4Tyj>|Tg(Pdx1-cre)89.1Dam|Kras<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Nabeel. Bardeesy, et.al., Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse., Proceedings of the National Academy of Sciences of the United States of America, 2006, 103
  http://rdf.ncbi.nlm.nih.gov/pubmed/16585505
• Andrew J. Aguirre, et.al., Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma., Genes & development, 2003, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/14681207
• Nabeel. Bardeesy, et.al., Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer., Genes & development, 2006, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/17114584