Anh T. Nguyen, et.al., DOT1L regulates dystrophin expression and is critical for cardiac function., Genes & development, 2011, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/21289070

Anh T. Nguyen, et.al., DOT1L regulates dystrophin expression and is critical for cardiac function., Genes & development, 2011, 25

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• prolonged QRS complex duration_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0010392NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• prolonged RR interval_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0010506NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• premature death_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0002083NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• dilated heart ventricle_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0008022NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• heart block_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0010559NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• cardiac interstitial fibrosis_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0005608NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• abnormal heart morphology_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0000266NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• dilated cardiomyopathy_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0002795NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• atrioventricular block_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0010519NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• increased heart left ventricle size_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0010579NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• decreased cardiac output_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0003393NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• enlarged heart_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0000274NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• abnormal muscle physiology_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0002106NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• prolonged P wave_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0004071NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• increased fetal cardiomyocyte proliferation_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0011394NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• increased cardiomyocyte apoptosis_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0003222NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• postnatal lethality, incomplete penetrance_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0011086NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• increased heart weight_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0002833NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel
• prolonged PR interval_Dot1l<tm1Tche>/Dot1l<tm1.1Tche>,Tg(Myhca-cre)1Abel/0
  http://metadb.riken.jp/0003896NSDot1ltm1TcheDot1ltm11TcheTgMyhcacre1Abel0Dot1ltm11TcheDot1ltm1TcheTgMyhcacre1Abel

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD35923
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD35923
• CD19607
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD19607
• CD17314
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD17314
• CD41754
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD41754
• CD18547
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD18547
• CD01184
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD01184
• CD22177
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD22177
• CD44451
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD44451
• CD00755
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00755
• CD15336
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD15336
• CD39494
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD39494
• CD14677
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD14677
• CD39351
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD39351
• CD40879
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40879
• CD22848
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD22848
• CD41631
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD41631
• CD16636
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD16636
• CD39414
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD39414
• CD39229
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD39229
• CD06355
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD06355
• CD16393
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD16393