Keiko. Fujikawa, et.al., Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells., The Journal of experimental medicine, 2003, 198

http://rdf.ncbi.nlm.nih.gov/pubmed/14623913

Keiko. Fujikawa, et.al., Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells., The Journal of experimental medicine, 2003, 198

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Vav3<tm1Swat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2683642

class

http://purl.org/net/cito/citesAsAuthority

• Vav3<tm1Swat>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2683642

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal T cell physiology_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0002444I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased thymocyte number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0000715I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased double-positive T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0005092I129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav3tm1SwatVav3tm1SwatVav3tm1SwatVav1tm1Tyb
• abnormal T cell physiology_Vav1<tm1Tyb>/Vav1<tm1Tyb>
  http://metadb.riken.jp/0002444I129S2SvPasVav1tm1TybVav1tm1TybVav1tm1Tyb
• decreased interleukin-2 secretion_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0008688I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased mature B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0008211I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased interferon-gamma secretion_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0008567I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased interferon-gamma secretion_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008567I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased IgM level_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0001806I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased transitional stage T2 B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0009926I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• no abnormal phenotype detected_Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0002169I129S6SvEvTacC57BL6Vav3tm1SwatVav3tm1SwatVav3tm1Swat
• decreased interleukin-2 secretion_Vav1<tm1Tyb>/Vav1<tm1Tyb>
  http://metadb.riken.jp/0008688I129S2SvPasVav1tm1TybVav1tm1TybVav1tm1Tyb
• decreased double-positive T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0005092I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased T cell proliferation_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0005095I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased interferon-gamma secretion_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008567I129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav3tm1SwatVav3tm1SwatVav3tm1SwatVav1tm1Tyb
• decreased IgG2b level_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008497I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased T cell proliferation_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0005095I129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav3tm1SwatVav3tm1SwatVav3tm1SwatVav1tm1Tyb
• increased immature B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008214I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• abnormal humoral immune response_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0001800I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased B cell proliferation_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0005093I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased thymocyte number_Vav1<tm1Tyb>/Vav1<tm1Tyb>
  http://metadb.riken.jp/0000715I129S2SvPasVav1tm1TybVav1tm1TybVav1tm1Tyb
• abnormal B cell physiology_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0002459I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased mature B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008211I129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav3tm1SwatVav3tm1SwatVav3tm1SwatVav1tm1Tyb
• decreased B cell proliferation_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0005093I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased single-positive T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0008083I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0005018I129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav3tm1SwatVav3tm1SwatVav3tm1SwatVav1tm1Tyb
• decreased B cell proliferation_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0005093I129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav3tm1SwatVav3tm1SwatVav3tm1SwatVav1tm1Tyb
• decreased single-positive T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008083I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased mature B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008211I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased immunoglobulin level_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0002460I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased T cell proliferation_Vav1<tm1Tyb>/Vav1<tm1Tyb>
  http://metadb.riken.jp/0005095I129S2SvPasVav1tm1TybVav1tm1TybVav1tm1Tyb
• arrested B cell differentiation_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0001802I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased double-positive T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0005092I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased mature B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>
  http://metadb.riken.jp/0008211I129S2SvPasVav1tm1TybVav1tm1TybVav1tm1Tyb
• decreased follicular B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008174I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased double-negative T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0005089I129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav3tm1SwatVav3tm1SwatVav3tm1SwatVav1tm1Tyb
• increased transitional stage T1 B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0009922I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased interferon-gamma secretion_Vav1<tm1Tyb>/Vav1<tm1Tyb>
  http://metadb.riken.jp/0008567I129S2SvPasVav1tm1TybVav1tm1TybVav1tm1Tyb
• decreased IgG3 level_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008498I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased interleukin-2 secretion_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008688I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased single-positive T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008083I129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav3tm1SwatVav3tm1SwatVav3tm1SwatVav1tm1Tyb
• decreased T cell proliferation_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0005095I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased marginal zone B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008182I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0005018I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased IgG1 level_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008495I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• arrested T cell differentiation_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0001825I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb
• decreased thymocyte number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0000715I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased double-negative T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>
  http://metadb.riken.jp/0005089I129S1Sv129S2SvPasVav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav1tm1TybVav2tm1Kdf
• decreased interleukin-2 secretion_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0008688I129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav3tm1SwatVav3tm1SwatVav3tm1SwatVav1tm1Tyb
• decreased T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>
  http://metadb.riken.jp/0005018I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD04143
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04143