Kohki. Kawane, et.al., Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages., Nature, 2006, 443

http://rdf.ncbi.nlm.nih.gov/pubmed/17066036

Kohki. Kawane, et.al., Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages., Nature, 2006, 443

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Dnase2a<tm2Osa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3691118

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating interleukin-18 level_Dnase2a<tm1Osa>/Dnase2a<tm2Osa>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008635I129S1Sv129S2SvPas129X1SvJC57BL6CBADnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn0Dnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn
• increased spleen red pulp amount_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0008476I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• rheumatoid arthritis_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0003561I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• abnormal cytokine level_Dnase2a<tm1Osa>/Dnase2a<tm2Osa>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008713I129S1Sv129S2SvPas129X1SvJC57BL6CBADnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn0Dnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn
• abnormal cytokine level_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0008713I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• abnormal macrophage morphology_Dnase2a<tm1Osa>/Dnase2a<tm2Osa>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002446I129S1Sv129S2SvPas129X1SvJC57BL6CBADnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn0Dnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn
• joint inflammation_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0002933I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• abnormal macrophage morphology_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0002446I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• enlarged spleen_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0000691I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• increased circulating interleukin-18 level_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0008635I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• increased circulating tumor necrosis factor level_Dnase2a<tm1Osa>/Dnase2a<tm2Osa>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008553I129S1Sv129S2SvPas129X1SvJC57BL6CBADnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn0Dnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn
• anemia_Dnase2a<tm1Osa>/Dnase2a<tm2Osa>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577I129S1Sv129S2SvPas129X1SvJC57BL6CBADnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn0Dnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn
• abnormal blood homeostasis_Dnase2a<tm1Osa>/Dnase2a<tm2Osa>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0009642I129S1Sv129S2SvPas129X1SvJC57BL6CBADnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn0Dnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn
• increased anti-double stranded DNA antibody level_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0004762I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• increased circulating tumor necrosis factor level_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0008553I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• anemia_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0001577I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• abnormal blood homeostasis_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0009642I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• joint inflammation_Dnase2a<tm1Osa>/Dnase2a<tm2Osa>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002933I129S1Sv129S2SvPas129X1SvJC57BL6CBADnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn0Dnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn
• postnatal growth retardation_Dnase2a<tm1Osa>/Dnase2a<tm2Osa>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001732I129S1Sv129S2SvPas129X1SvJC57BL6CBADnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn0Dnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn
• postnatal growth retardation_Dnase2a<tm1Osa>/Dnase2a<tm1Osa>,Ifnar1<tm1Agt>/Ifnar1<tm1Agt>
  http://metadb.riken.jp/0001732I129S1Sv129S2SvPas129X1SvJC57BL6Dnase2atm1OsaDnase2atm1OsaIfnar1tm1AgtIfnar1tm1AgtIfnar1tm1AgtDnase2atm1Osa
• rheumatoid arthritis_Dnase2a<tm1Osa>/Dnase2a<tm2Osa>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003561I129S1Sv129S2SvPas129X1SvJC57BL6CBADnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn0Dnase2atm1OsaDnase2atm2OsaTgMx1cre1Cgn

class

http://purl.org/net/cito/citesAsAuthority

• Dnase2a<tm2Osa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3691118

article

http://www.w3.org/2000/01/rdf-schema#seeAlso

• [Blank]
• [Blank]

BRC マウスの系統

http://purl.org/net/cito/citesAsAuthority

• B6.129-Dnase2a<tm1Osa> Ifnar1<tm1Agt>
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC04021
• B6.129-Dnase2a<tm2.1Osa>
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC04020

article

http://www.w3.org/2000/01/rdf-schema#seeAlso

• [Blank]
• [Blank]