Mark M W. Chong, et.al., The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease., The Journal of experimental medicine, 2008, 205

http://rdf.ncbi.nlm.nih.gov/pubmed/18725527

Mark M W. Chong, et.al., The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease., The Journal of experimental medicine, 2008, 205

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Drosha<tm1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3801076
• Drosha<tm1.1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3806089

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased regulatory T cell number_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004974I129C57BL6DBA2Dicer1tm1BdhDicer1tm1BdhTgCd4cre1Cwi0TgCd4cre1CwiDicer1tm1Bdh
• liver inflammation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001860I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• enlarged spleen_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0000691I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDicer1tm1Bdh
• premature death_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• enlarged spleen_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0000691I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• enlarged lymph nodes_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0000702I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• liver inflammation_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0001860I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDicer1tm1Bdh
• abnormal interferon-gamma secretion_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0008559I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• lung inflammation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001861I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• increased CD8-positive, alpha-beta T cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0008078I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• abnormal interleukin-4 secretion_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0008698I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• lung inflammation_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0001861I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDicer1tm1Bdh
• enlarged spleen_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0000691I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrYDicer1tm1BdhFoxp3tm4YFPicreAyr
• abnormal immune system physiology_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001790I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• lung inflammation_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0001861I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrYDicer1tm1BdhFoxp3tm4YFPicreAyr
• enlarged spleen_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0000691I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• enlarged lymph nodes_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0000702I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• premature death_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• increased granulocyte number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000322I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• decreased skeletal muscle mass_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004819I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• liver inflammation_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0001860I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrYDicer1tm1BdhFoxp3tm4YFPicreAyr
• abnormal interferon-gamma secretion_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0008559I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• liver inflammation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0001860I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• vascular inflammation_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0001863I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDicer1tm1Bdh
• vascular inflammation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0001863I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• increased gamma-delta T cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008346I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• premature death_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrYDicer1tm1BdhFoxp3tm4YFPicreAyr
• abnormal T cell activation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0001828I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• abnormal interferon-gamma secretion_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008559I129129P2OlaHsdC57BL6FVBNDroshatm1LittDroshatm11LittGtROSA26Sortm1creERTNatGtROSA26SorDroshatm1LittDroshatm11LittGtROSA26Sortm1creERTNatGtROSA26Sor
• liver inflammation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0001860I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• lung inflammation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0001861I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• intestinal inflammation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001858I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• increased CD8-positive, alpha-beta T cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0008078I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• enlarged lymph nodes_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0000702I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDicer1tm1Bdh
• premature death_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDicer1tm1Bdh
• increased leukocyte cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0000218I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrYFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• abnormal interleukin-4 secretion_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0008698I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• enlarged lymph nodes_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0000702I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrYDicer1tm1BdhFoxp3tm4YFPicreAyr
• increased leukocyte cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0000218I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• lung inflammation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0001861I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• premature death_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• abnormal regulatory T cell morphology_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0004941I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• vascular inflammation_Dicer1<tm1Bdh>/Dicer1<tm1Bdh>,Foxp3<tm4(YFP/icre)Ayr>/Y
  http://metadb.riken.jp/0001863I129S1Sv129X1SvJDicer1tm1BdhDicer1tm1BdhFoxp3tm4YFPicreAyrYDicer1tm1BdhFoxp3tm4YFPicreAyr
• vascular inflammation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0001863I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• increased activated T cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001829I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• decreased double-positive T cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005092I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• decreased thymocyte number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000715I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• decreased lymphocyte cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005016I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• decreased regulatory T cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004974I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• decreased CD8-positive, alpha-beta T cell number_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008079I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• decreased body fat mass_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0014143I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi
• abnormal T cell activation_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<tm4(YFP/icre)Ayr>
  http://metadb.riken.jp/0001828I129S1Sv129X1SvJC57BL6FVBNDroshatm1LittDroshatm11LittFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrFoxp3tm4YFPicreAyrDroshatm1LittDroshatm11Litt
• cachexia_Drosha<tm1Litt>/Drosha<tm1.1Litt>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005150I129P2OlaHsdC57BL6DBA2FVBNDroshatm1LittDroshatm11LittTgCd4cre1Cwi0Droshatm1LittDroshatm11LittTgCd4cre1Cwi

class

http://purl.org/net/cito/citesAsAuthority

• Drosha<tm1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3801076
• Drosha<tm1.1Litt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3806089