Bigang. Liu, et.al., IKKalpha is required to maintain skin homeostasis and prevent skin cancer., Cancer cell, 2008, 14

http://rdf.ncbi.nlm.nih.gov/pubmed/18772111

Bigang. Liu, et.al., IKKalpha is required to maintain skin homeostasis and prevent skin cancer., Cancer cell, 2008, 14

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Chuk<tm1Yhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3817541

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• thick skin_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001200B6CgChuktm1YhuTgKRT5cre5132JljChuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0TgKRT5cre5132JljChuktm1Yhu
• premature death_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Egfr<wa2>/Egfr<wa2>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuEgfrwa2Egfrwa2TgKRT5cre5132Jlj0Egfrwa2Chuktm1YhuTgKRT5cre5132Jlj
• postnatal lethality, complete penetrance_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Egfr<tm1Mag>/Egfr<tm1Mag>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0011085I129C57BL6CD1Chuktm1YhuChuktm1YhuEgfrtm1MagEgfrtm1MagTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132JljEgfrtm1Mag
• increased skin tumor incidence_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(Krt1-5-cre/ERT)1Ipc/0
  http://metadb.riken.jp/0010300I129S1Sv129X1SvJC57BL6SJLChuktm1YhuChuktm1YhuTgKrt15creERT1Ipc0Chuktm1YhuTgKrt15creERT1Ipc
• abnormal skeleton morphology_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0005508I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• increased keratinocyte proliferation_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0009583I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• thick skin_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001200FVBCgChuktm1YhuTgKRT5cre5132JljChuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• postnatal lethality_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tnfrsf1a<tm1Mak>/Tnfrsf1a<tm1Mak>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0002082I129S1Sv129S2SvPas129X1SvJC57BL6Chuktm1YhuChuktm1YhuTnfrsf1atm1MakTnfrsf1atm1MakTgKRT5cre5132Jlj0Tnfrsf1atm1MakTgKRT5cre5132JljChuktm1Yhu
• epidermal hyperplasia_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001222I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• premature death_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Egfr<tm1Mag>/Egfr<+>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0002083I129C57BL6CD1Chuktm1YhuChuktm1YhuEgfrtm1MagEgfrTgKRT5cre5132Jlj0TgKRT5cre5132JljEgfrtm1MagChuktm1YhuEgfr
• abnormal eye morphology_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Egfr<tm1Mag>/Egfr<+>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0002092I129C57BL6CD1Chuktm1YhuChuktm1YhuEgfrtm1MagEgfrTgKRT5cre5132Jlj0TgKRT5cre5132JljEgfrtm1MagChuktm1YhuEgfr
• small esophagus_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0010880I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• abnormal coat/ hair morphology_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Egfr<tm1Mag>/Egfr<+>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0000367I129C57BL6CD1Chuktm1YhuChuktm1YhuEgfrtm1MagEgfrTgKRT5cre5132Jlj0TgKRT5cre5132JljEgfrtm1MagChuktm1YhuEgfr
• increased skin tumor incidence_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(MMTV-cre)4Mam/0
  http://metadb.riken.jp/0010300I129S1Sv129X1SvJC57BL6FVBChuktm1YhuChuktm1YhuTgMMTVcre4Mam0Chuktm1YhuTgMMTVcre4Mam
• epidermal hyperplasia_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(MMTV-cre)4Mam/0
  http://metadb.riken.jp/0001222I129S1Sv129X1SvJC57BL6FVBChuktm1YhuChuktm1YhuTgMMTVcre4Mam0Chuktm1YhuTgMMTVcre4Mam
• postnatal lethality, complete penetrance_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0011085FVBCgChuktm1YhuTgKRT5cre5132JljChuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• sparse hair_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(MMTV-cre)4Mam/0
  http://metadb.riken.jp/0000416I129S1Sv129X1SvJC57BL6FVBChuktm1YhuChuktm1YhuTgMMTVcre4Mam0Chuktm1YhuTgMMTVcre4Mam
• abnormal skin morphology_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT14-cre)1Cgn/0
  http://metadb.riken.jp/0002060I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT14cre1Cgn0TgKRT14cre1CgnChuktm1Yhu
• abnormal skin morphology_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0002060I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• postnatal growth retardation_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001732I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• thick epidermis_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tnfrsf1a<tm1Mak>/Tnfrsf1a<tm1Mak>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001219I129S1Sv129S2SvPas129X1SvJC57BL6Chuktm1YhuChuktm1YhuTnfrsf1atm1MakTnfrsf1atm1MakTgKRT5cre5132Jlj0Tnfrsf1atm1MakTgKRT5cre5132JljChuktm1Yhu
• postnatal lethality, complete penetrance_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0011085I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• thick skin_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001200I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• thick epidermis_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001219I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• increased skin tumor incidence_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0010300I129S1Sv129X1SvJC57BL6SJLChuktm1YhuChuktm1YhuTgKrt115crePGR22Cot0TgKrt115crePGR22CotChuktm1Yhu
• increased carcinoma incidence_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0002038I129S1Sv129X1SvJC57BL6SJLChuktm1YhuChuktm1YhuTgKrt115crePGR22Cot0TgKrt115crePGR22CotChuktm1Yhu
• epidermal hyperplasia_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT14-cre)1Cgn/0
  http://metadb.riken.jp/0001222I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT14cre1Cgn0TgKRT14cre1CgnChuktm1Yhu
• abnormal epidermal layer morphology_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Egfr<wa2>/Egfr<wa2>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001216I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuEgfrwa2Egfrwa2TgKRT5cre5132Jlj0Egfrwa2Chuktm1YhuTgKRT5cre5132Jlj
• postnatal lethality, complete penetrance_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0011085B6CgChuktm1YhuTgKRT5cre5132JljChuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0TgKRT5cre5132JljChuktm1Yhu
• thick epidermis_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Egfr<tm1Mag>/Egfr<+>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001219I129C57BL6CD1Chuktm1YhuChuktm1YhuEgfrtm1MagEgfrTgKRT5cre5132Jlj0TgKRT5cre5132JljEgfrtm1MagChuktm1YhuEgfr
• decreased survivor rate_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Egfr<tm1Mag>/Egfr<+>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0008770I129C57BL6CD1Chuktm1YhuChuktm1YhuEgfrtm1MagEgfrTgKRT5cre5132Jlj0TgKRT5cre5132JljEgfrtm1MagChuktm1YhuEgfr
• epidermal hyperplasia_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(Krt1-5-cre/ERT)1Ipc/0
  http://metadb.riken.jp/0001222I129S1Sv129X1SvJC57BL6SJLChuktm1YhuChuktm1YhuTgKrt15creERT1Ipc0Chuktm1YhuTgKrt15creERT1Ipc
• wrinkled skin_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001211I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj
• epidermal hyperplasia_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tnfrsf1a<tm1Mak>/Tnfrsf1a<tm1Mak>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001222I129S1Sv129S2SvPas129X1SvJC57BL6Chuktm1YhuChuktm1YhuTnfrsf1atm1MakTnfrsf1atm1MakTgKRT5cre5132Jlj0Tnfrsf1atm1MakTgKRT5cre5132JljChuktm1Yhu
• increased skin papilloma incidence_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0002051I129S1Sv129X1SvJC57BL6SJLChuktm1YhuChuktm1YhuTgKrt115crePGR22Cot0TgKrt115crePGR22CotChuktm1Yhu
• abnormal keratinocyte differentiation_Chuk<tm1Yhu>/Chuk<tm1Yhu>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0002656I129S1Sv129X1SvJC57BL6Chuktm1YhuChuktm1YhuTgKRT5cre5132Jlj0Chuktm1YhuTgKRT5cre5132Jlj

class

http://purl.org/net/cito/citesAsAuthority

• Chuk<tm1Yhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3817541