Franck. Toledo, et.al., A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network., Cancer cell, 2006, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/16616333

Franck. Toledo, et.al., A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network., Cancer cell, 2006, 9

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased apoptosis in RBRC09248
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010888

allele

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm3Wahl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3624429

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased tumor incidence_Trp53<tm1Wahl>/Trp53<tm1Wahl>
  http://metadb.riken.jp/0002020IC57BL6Trp53tm1WahlTrp53tm1WahlTrp53tm1Wahl
• abnormal cell cycle_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm3Wahl>/Trp53<tm3Wahl>
  http://metadb.riken.jp/0003077I129S4SvJae129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm3WahlTrp53tm3WahlTrp53tm3WahlMdm4GtVICTR207Lex
• abnormal cell cycle_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<Gt(VICTR20)7Lex>/Mdm4<+>,Trp53<tm1Wahl>/Trp53<tm1Wahl>
  http://metadb.riken.jp/0003077I129S5SvEvBrd129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4GtVICTR207LexMdm4Trp53tm1WahlTrp53tm1WahlMdm4Mdm4GtVICTR207LexMdm2tm1GloTrp53tm1WahlMdm2
• prenatal lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm1Wahl>/Trp53<tm1Wahl>
  http://metadb.riken.jp/0011091I129S7SvEvBrdC57BL6Mdm2tm1GloMdm2tm1GloTrp53tm1WahlTrp53tm1WahlMdm2tm1GloTrp53tm1Wahl
• decreased cell proliferation_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm1Wahl>/Trp53<tm1Wahl>
  http://metadb.riken.jp/0000352I129S5SvEvBrdC57BL6Mdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm1WahlTrp53tm1WahlMdm4GtVICTR207LexTrp53tm1Wahl
• abnormal cell cycle_Mdm4<Gt(VICTR20)7Lex>/Mdm4<+>,Trp53<tm1Wahl>/Trp53<tm1Wahl>
  http://metadb.riken.jp/0003077I129S5SvEvBrdC57BL6Mdm4GtVICTR207LexMdm4Trp53tm1WahlTrp53tm1WahlMdm4Mdm4GtVICTR207LexTrp53tm1Wahl
• increased tumor latency_Trp53<tm3Wahl>/Trp53<tm3Wahl>
  http://metadb.riken.jp/0009828I129S4SvJaeTrp53tm3WahlTrp53tm3WahlTrp53tm3Wahl
• increased tumor incidence_Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0002020I129S7SvEvBrdC57BL6Trp53tm1BrdTrp53tm1BrdTrp53tm1Brd
• abnormal cell cycle_Trp53<tm3Wahl>/Trp53<tm3Wahl>
  http://metadb.riken.jp/0003077I129S4SvJaeTrp53tm3WahlTrp53tm3WahlTrp53tm3Wahl
• abnormal cell cycle_Mdm2<tm1Glo>/Mdm2<+>,Trp53<tm3Wahl>/Trp53<tm3Wahl>
  http://metadb.riken.jp/0003077I129S4SvJae129S7SvEvBrdMdm2tm1GloMdm2Trp53tm3WahlTrp53tm3WahlMdm2tm1GloMdm2Trp53tm3Wahl
• prenatal lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm3Wahl>/Trp53<tm3Wahl>
  http://metadb.riken.jp/0011091I129S4SvJae129S7SvEvBrdMdm2tm1GloMdm2tm1GloTrp53tm3WahlTrp53tm3WahlMdm2tm1GloTrp53tm3Wahl
• increased tumor incidence_Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0002020I129S7SvEvBrdTrp53tm1BrdTrp53tm1BrdTrp53tm1Brd
• decreased fibroblast apoptosis_Trp53<tm1Wahl>/Trp53<tm1Wahl>
  http://metadb.riken.jp/0013502IC57BL6Trp53tm1WahlTrp53tm1WahlTrp53tm1Wahl
• abnormal cell cycle_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm1Wahl>/Trp53<tm1Wahl>
  http://metadb.riken.jp/0003077I129S5SvEvBrdC57BL6Mdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm1WahlTrp53tm1WahlMdm4GtVICTR207LexTrp53tm1Wahl
• decreased apoptosis_Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0006043I129S7SvEvBrdC57BL6Trp53tm1BrdTrp53tm1BrdTrp53tm1Brd
• abnormal cell cycle_Mdm2<tm1Glo>/Mdm2<+>,Trp53<tm1Wahl>/Trp53<tm1Wahl>
  http://metadb.riken.jp/0003077I129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Trp53tm1WahlTrp53tm1WahlMdm2tm1GloTrp53tm1WahlMdm2
• abnormal cell cycle_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<Gt(VICTR20)7Lex>/Mdm4<+>,Trp53<tm3Wahl>/Trp53<tm3Wahl>
  http://metadb.riken.jp/0003077I129Mdm2tm1GloMdm2Mdm4GtVICTR207LexMdm4Trp53tm3WahlTrp53tm3WahlMdm2Trp53tm3WahlMdm4Mdm2tm1GloMdm4GtVICTR207Lex
• decreased fibroblast proliferation_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm3Wahl>/Trp53<tm3Wahl>
  http://metadb.riken.jp/0011704I129S4SvJae129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm3WahlTrp53tm3WahlTrp53tm3WahlMdm4GtVICTR207Lex
• decreased apoptosis_Trp53<tm3Wahl>/Trp53<tm3Wahl>
  http://metadb.riken.jp/0006043I129S4SvJaeTrp53tm3WahlTrp53tm3WahlTrp53tm3Wahl
• increased cell proliferation_Trp53<tm3Wahl>/Trp53<tm3Wahl>
  http://metadb.riken.jp/0000351I129S4SvJaeTrp53tm3WahlTrp53tm3WahlTrp53tm3Wahl